TAK-778 [(2R,4S)-(−)-N-(4-diethoxyphosphorylmethylphenyl)-1,2,4,5-tetrahydro-4-methyl-7,8-methylenedioxy-5-oxo-3-benzothiepin-2-carboxyamide;
mw 505.53], a novel osteoblast …

Complexes of cis-diamminedichloroplatinum(II) (cisplatin) and transferrin (Tf(Fe) 2 ) of differing
molar ratios (Pt Tf 3:1, 7:1, and 15:1 mol/mol) were prepared. Tf-receptor binding studies …

The feasibility of using microcapsules containing a bone formation stimulant, (2R,4S)‐(−)‐N‐(4‐diethoxyphosphorylmethylphenyl)‐1,2,4,5‐tetrahydro‐4‐methyl‐7,8‐methylenedioxy‐5‐…

TAK-778, a novel synthetic 3-benzothiepin derivative, stimulates the formation of cartilaginous
nodules in mouse chondroprogenitor-like ATDC5 cells in vitro in association with …

A pharmacokinetic investigation on the urinary excretion of clavulanic acid in man was carried
out. Combinations of clavulanic acid (125 mg) and amoxicillin (250 mg) were given orally …

The benzothiepin derivative (2R,4S)‐(‐)‐N‐(4‐diethoxyphosphorylmethylphenyl)‐1,2,4,5‐tetrahydro‐4‐methyl‐7,8‐methylenedioxy‐5‐oxo‐3‐benzothiepin‐2‐carboxamide
(TAK‐778) …

The fluorescence intensity of a unique tryptohan 36 in human interferon-γ was drastically
decreased below pH 4 with a concomitant decrease of antiviral activity. The region of residues …

Background and Aims: A relatively large number of patients with multiple myeloma have been
reported to develop a secondary malignancy such as cancer of the breast, biliary system …

There have been only a few endoscopic studies with respect to lower intestinal lesions of
leukaemia and malignant lymphoma, although there have been many autopsy studies of these …

Cuttings transport in aerated mud drilling for inclined annuli with inclination angles between
30 to horizontal was investigated. Experiments were carried out for over 300 flow conditions …