Observational clinical and ex vivo studies have established a strong association between
atrial fibrillation and inflammation 1 . However, whether inflammation is the cause or the …

Electrophilic fatty acids are generated during inflammation by non-enzymatic reactions and
can modulate inflammatory responses. We used a new mass spectrometry–based …

Background— Neutrophils and monocytes are centrally linked to vascular inflammatory
disease, and leukocyte-derived myeloperoxidase (MPO) has emerged as an important …

Over the last 50 years, the posttranslational modification (PTM) of proteins has emerged as
a central mechanism for cells to regulate metabolism, growth, differentiation, cell-cell …

Aims Nitrated fatty acids (NO 2 -FA) have been identified as endogenous anti-inflammatory
signalling mediators generated by oxidative inflammatory reactions. Herein the in vivo …

Objectives : The aim of this study was to identify predictors of permanent pacemaker
implantation (PPMI) following transcatheter aortic valve replacement (TAVR) with a balloon-…

Recruitment of polymorphonuclear neutrophils (PMNs) remains a paramount prerequisite in
innate immune defense and a critical cofounder in inflammatory vascular disease. …

The peroxisome proliferator-activated receptor-γ (PPARγ) binds diverse ligands to transcriptionally
regulate metabolism and inflammation. Activators of PPARγ include lipids and anti-…

Objective— Inflammatory processes and foam cell formation are key determinants in the
initiation and progression of atherosclerosis. Electrophilic nitro–fatty acids, byproducts of nitric …

Background Among low-risk patients with severe, symptomatic aortic stenosis who are
eligible for both transcatheter aortic-valve implantation (TAVI) and surgical aortic-valve …