Since the peripheral benzodiazepine receptor (PBR) has been primarily found as a high-affinity
binding site for diazepam in rat kidney, numerous studies of it have been performed. …

Receptor binding and behavioral profiles of N-(4-chloro-2-phenoxyphenyl)-N-(2-isopropoxybenzyl)acetamide
(DAA1097) and N-(2,5-dimethoxybenzyl)-N-(5-fluoro-2-phenoxyphenyl)…

The concept of drug-likeness, an important characteristic for any compound in a screening
library, is nevertheless difficult to pin down. Based on our belief that this concept is implicit …

We investigated the effects of a novel melanocortin-4 (MC4) receptor antagonist,1-[(S)-2-(4-fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]…

Receptor binding, behavioral, and electrophysiological profiles of 2-[N-(2-methylthio-4-isopropylphenyl)-N-ethylamino]-4-[4-(3-fluorophenyl)-1,2,3,6-tetrahydropyridin-1-yl)-6-…

Here, we investigated the binding characteristics of [ 3 H ]N-(2,5-dimethoxybenzyl)-N-(5-fluoro-2-phenoxyphenyl)acetamide
([ 3 H ]DAA1106), a potent and selective ligand for …

The peripheral benzodiazepine receptor (PBR) is pharmacologically distinct from the central
benzodiazepine receptor (CBR) and has been identified in a wide range of peripheral …

Derived from proopiomelanocortin by proteolytic processing, melanocortins have been
implicated in a wide range of physiological processes. Melanocortins exert their physiological …

Although currently prescribed antidepressants with actions mediated through alteration of
monoaminergic transmission have been proven to be useful for the treatment of depressive …

In the present study, we examined the anxiolytic and antidepressant effects of MCL0042, a
novel compound showing activity in both MC4 receptor antagonism and serotonin transporter …