The effects of topical application of arachidonic acid (AA) or phorbol ester, tetradecanoylphorbol
13-acetate (TPA), on edema response, vascular permeability, MPO, NAG, and …

FTY720 is a prodrug for FTY-phosphate, an agonist at four of the five known receptors for
sphingosine-1-phosphate (S1P). We show that administration of either FTY720 or FTY-P to SJL …

Demyelination is a hallmark of several human diseases, including multiple sclerosis. To
understand better the process of demyelination and remyelination, we explored the use of an in …

We used a simple commercial magnetic immunobead method for the preparation of acutely
isolated microglial cells from postnatal days 1–3 rat brain. With the exception of a 15min …

Lysophosphatidic acid (LPA) and sphingosine‐1‐phosphate (S1P) have been proposed to
play a key role in oligodendrocyte maturation and myelinogenesis. In this study, we …

Intraperitoneal administration of zymosan to mice resulted in marked biosynthesis of
eicosanoids and influx of neutrophils with distinct time course profiles. 6-Keto-prostaglandin-F1 …

Lysophosphatidic acid (1-acyl-2-lyso-sn-glycero-3-phosphate; LPA) and sphingosine-1-phosphate
(S1P) are bioactive phospholipids which respectively act as agonists for the G-protein…

There are three isoforms of dimeric nitric oxide synthases (NOS) that convert arginine to
citrulline and nitric oxide. Inducible NOS is implicated in numerous inflammatory diseases and, …

Three isoforms of nitric oxide synthase (NOS), dimeric enzymes that catalyze the formation
of nitric oxide (NO) from arginine, have been identified. Inappropriate or excessive NO …

Phosphatidylinositol‐3‐kinase gamma (PI3Kγ) is a leukocyte‐specific lipid kinase with
signaling function downstream of G protein‐coupled receptors to regulate cell trafficking, but its …