Polyunsaturated fatty acids (PUFAs) affect cardiac excitability. Kv7.1 and the β-subunit
KCNE1 form the cardiac I Ks channel that is central for cardiac repolarization. In this study, we …

… Rantanen was Medical Head at Espoo City Hospital, and T. Parkkari is an employee of
Clinius Ltd., a contract research organization (CRO) that provides support and services for …

In the present study, identification of chiral 1,3,4-oxadiazol-2-ones as potent and selective
FAAH inhibitors has been described. The separated enantiomers showed clear differences in …

… sample t-test with the mean value compared to a hypothetical value of 0. For comparison of
shifts at different pH two-tailed unpaired t-test was used; p < 0.05 is considered as significant. …

Background Human lymphocyte antigen B-associated transcript 5 (BAT5, also known as
ABHD16A) is a poorly characterized 63 kDa protein belonging to the α/β-hydrolase domain (…

Compound 12a (JZP-361) acted as a potent and reversible inhibitor of human recombinant
MAGL (hMAGL, IC 50 = 46 nM), and was found to have almost 150-fold higher selectivity …

… process in MS, thus in order to address potential different effects between cells derived
from patients and healthy controls, we evaluated the efficacy of our compounds on some T cell …

… Comparison between IC 50 mean values was obtained by the Student’s t test analysis for …
Comparison between IC 50 mean values was obtained by the Student’s t test analysis for …

Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by
severe disruption of cognitive and motor functions, including changes in posture and gait. A …

At present, inhibitors of α/β‐hydrolase domain 6 (ABHD6) are viewed as a promising approach
to treat inflammation and metabolic disorders. This article describes the development of 1,…