Neuronal ion channels as the target sites of insecticides

T Narahashi - Pharmacology & toxicology, 1996 - Wiley Online Library
… Brown, LD & T. Narahashi: Modulation of nerve membrane sodium channel activation by
deltamethrin. Brain Res. 1992, 584, … Vijverberg & T. …

Sodium and GABA-activated channels as the targets of pyrethroids and cyclodienes

T Narahashi, JM Frey, KS Ginsburg, ML Roy - Toxicology letters, 1992 - Elsevier
The symptoms of poisoning by the pyrethroid and cyclodiene insecticides are characterized
by hyperexcitation and convulsions followed by paralysis. The main target site of the …

Chemicals as tools in the study of excitable membranes.

T Narahashi - Physiological Reviews, 1974 - journals.physiology.org
It is by no means a new idea to utilize a variety of drugs and chemicals as tools for the study
of neurophysiology. Some 80 years ago, Langley took full advantage of the synaptic …

Tetrodotoxin blockage of sodium conductance increase in lobster giant axons

T Narahashi, JW Moore, WR Scott - The Journal of general physiology, 1964 - rupress.org
Narahashi's present address is the … NARAHASHI, T., Restoration of action potential by
anodal polarization in lobster giant axons, data to be published, 1964 a. NARAHASHI, T., …

Differential properties of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons

ML Roy, T Narahashi - Journal of Neuroscience, 1992 - Soc Neuroscience
… with externally applied divalent cations (Roy and Narahashi, 199 1). Developmental
expression of these channels has also been reported (Roy and Narahashi, 1990; Schwartz et al., …

α-Thujone (the active component of absinthe): γ-aminobutyric acid type A receptor modulation and metabolic detoxification

…, NS Sirisoma, T Ikeda, T Narahashi… - Proceedings of the …, 2000 - National Acad Sciences
α-Thujone is the toxic agent in absinthe, a liqueur popular in the 19th and early 20th centuries
that has adverse health effects. It is also the active ingredient of wormwood oil and some …

Neuroreceptors and ion channels as the basis for drug action: past, present, and future

T Narahashi - Journal of Pharmacology and Experimental …, 2000 - ASPET
This article summarizes the development of cellular neuropharmacology and neurotoxicology,
based primarily on my own research. The progress of this field depends at least in part on …

Mode of action of pyrethroids

T Narahashi - Bulletin of the World Health Organization, 1971 - ncbi.nlm.nih.gov
Since pyrethroids are potent neuropoisons, their mechanism of action on the nervous system
can best be studied by means of electrophysiological techniques. The nerve excitation …

Kinetics of sodium channel modification as the basis for the variation in the nerve membrane effects of pyrethroids and DDT analogs

AE Lund, T Narahashi - Pesticide Biochemistry and Physiology, 1983 - Elsevier
T Narahashi, Site and types of action of pyrethroids on nerve membrane, in “Pyrethroids
Insecticides: Chemistry and Action” (J. Mathieu, Ed.), Table Ronde Roussel Uclaf No. 37, p. …

The site of action and active form of local anesthetics. II. Experiments with quaternary compounds

DT FRAZIER, T NARAHASHI, M YAMADA - Journal of Pharmacology and …, 1970 - ASPET
The hypothesis concerning the active form and the site of action of tertiary amine local
anesthetics (Narahashi et al., 1970) predicts that there should be certain quaternary compounds …