… Dunwiddie 1999b). Exogenously administered adenosine receptor agonists reduce seizure
activity (… interactions has been discussed extensively in a recent review (Dunwiddie 1999a). …

BB Fredholm and TV Dunwiddie Page 1 BB Fredholm and TV Dunwiddie Adenosine is able
to decrease the release of most neurotransmitters. This is consistent with its general role in …

Publisher Summary This chapter discusses the physiological role of adenosine in the central
nervous system (CNS). In particular, the chapter's attention is directed to the actions of …

… and Dunwiddie, TV, Differential sensitivity of cerebellar Purkinje neurons to ethanol in
selectively outbred lines of mice: maintenance in vitro independent of synaptic transmission, Brain …

Caffeine is believed to act by blocking adenosine A 1 and A 2A receptors (A 1 R, A 2A R),
indicating that some A 1 receptors are tonically activated. We generated mice with a targeted …

There are multiple mechanisms by which adenine nucleotides can be released into the
extracellular space in brain. Adenine nucleotides are converted extracellularly to adenosine, …

ABSTRACT Dunwiddie, Thomas V. and Thomas Worth: Sedative and anticonvulsant effects
of adenosine analogs in mouse and rat.

The effects of acetylcholine on both pyramidal neurons and interneurons in the area CA1 of
the rat hippocampus were examined, using intracellular recording techniques in an in …

The CNS abundantly expresses P2X receptor channels for ATP; of these the most widespread
in the brain is the P2X 4 channel. We show that ivermectin (IVM) is a specific positive …

Exogenous application of acetylcholine elicits inward currents in hippocampal interneurons
that are mediated via α-bungarotoxin-sensitive nicotinic acetylcholine receptors, but synaptic …