A chronic mouse model of myocardial ischemia-reperfusion: essential in cytokine studies

TO Nossuli, V Lakshminarayanan… - American Journal …, 2000 - journals.physiology.org
Reperfusion of the ischemic myocardium is associated with a cytokine cascade that reflects
a cellular response to injury. We studied this cascade in the mouse and found that acute …

Regulation of P-selectin expression in human endothelial cells by nitric oxide

…, RA Schuhl, R Hayward, TO Nossuli… - American Journal …, 1997 - journals.physiology.org
… Therefore the purpose of this study was to determine whether NO exerts a physiological …
to its well-known effect of regulating translocation of intracellular P-selectin to the cell surface. …

Hemodynamically-guided management of heart failure across the ejection fraction spectrum: the GUIDE-HF trial

…, S Paul, F Smart, G Grafton, S Kumar, TO Nossuli… - Heart Failure, 2022 - jacc.org
… blinded to their study group assignment and having no access to their PA … to manage patients
accordingly but did not have access to PA … relevant to the contents of this paper to disclose. …

Mechanisms of cardioprotection by peroxynitrite in myocardial ischemia and reperfusion injury

TO Nossuli, R Hayward, D Jensen… - American Journal of …, 1998 - journals.physiology.org
… Physiological concentrations of NO occur in the range of 1–20 nM (13) and are thought to
increase to maximal levels in the low micromolar range (ie, 2–5 μM) in disease states when …

Brief murine myocardial I/R induces chemokines in a TNF-α-independent manner: role of oxygen radicals

TO Nossuli, NG Frangogiannis… - American Journal …, 2001 - journals.physiology.org
… We presume that the failure to find statistical significance relates to a greater variability in
the level of MIP-1β in sham-operated animals. The balance of the data appears …

Protection from myocardial reperfusion injury by acute administration of 17β-estradiol

JA Delyani, T Murohara, TO Nossuli… - Journal of molecular and …, 1996 - Elsevier
… chronic exposure to estrogen appears to be cardioprotective, … Cats were subjected to 90 min
of left anterior descending … was administered (iv) 30 min prior to reperfusion at 1μg/kg bolus …

Cardioprotective effect of interleukin-10 in murine myocardial ischemia-reperfusion

R Hayward, TO Nossuli, R Scalia, AM Lefer - European journal of …, 1997 - Elsevier
… in order to determine whether a single dose of rat interleukin-10 is able to protect against …
A second goal was to observe the effects of rat interleukin-10 on leukocyte–endothelial …

Peroxynitrite reduces myocardial infarct size and preserves coronary endothelium after ischemia and reperfusion in cats

TO Nossuli, R Hayward, R Scalia, AM Lefer - Circulation, 1997 - Am Heart Assoc
… ischemic myocardium was allowed to reperfuse for 270 minutes. … of ONOO − to achieve
circulating levels of 400 to 1000 nmol/L … − to alter adherence of autologous unstimulated PMNs to

S-nitrosylated tissue-type plasminogen activator protects against myocardial ischemia/reperfusion injury in cats: role of the endothelium.

JA Delyani, TO Nossuli, R Scalia, G Thomas… - … of Pharmacology and …, 1996 - ASPET
… nitric oxide donor properties to the molecule. Cats were subjected to 90 min of myocardial
ischemia … descending coronary artery rings in response to the endothelium-dependent dilators …

Myocardial protection by N,N,N-trimethylsphingosine in ischemia reperfusion injury is mediated by inhibition of P-selectin

…, T Murohara, JA Delyani, TO Nossuli… - Journal of Leucocyte …, 1996 - academic.oup.com
… and adherence to the rat microvascular endothelium. This action of TMS appears to be
mediated … In conclusion, TMS seems to be an effective cardioprotective agent by inhibiting early …