The covalent-binding reaction of complement component C3

RB Sim, TM Twose, DS Paterson, E Sim - Biochemical Journal, 1981 - portlandpress.com
The complement protein C3, when activated by limited proteolysis, forms a short-lived reactive
intermediate fragment, ‘nascent’ C3b, which is known to bind covalently to certain surfaces…

Native Type II Collagen‐Induced Arthritis in the Rat

…, MJ Shaw, SA Firth, TM Twose… - … : Official Journal of …, 1981 - Wiley Online Library
Antibodies to native bovine type II collagen may be important in initiating arthritis in rats
immunized with this antigen. The cross‐reactivity of these antibodies with native rat type II …

The selective M1 muscarinic cholinergic agonist CDD-0102A enhances working memory and cognitive flexibility

ME Ragozzino, S Artis, A Singh, TM Twose… - … of Pharmacology and …, 2012 - ASPET
Various neurodegenerative diseases and psychiatric disorders are marked by alterations in
brain cholinergic function and cognitive deficits. Efforts to alleviate such deficits have been …

Denaturation mapping of R factor deoxyribonucleic acid

D Perlman, TM Twose, MJ Holland… - Journal of …, 1975 - Am Soc Microbiol
… It was expected that the 8.3-;tm r-determinants component DNA (58% G + C) would be
less denatured than the RTF-TC DNA (50% G + C) because it has a higher G + C content. We …

Do mammalian collagenases and DNA restriction endonucleases share a similar mechanism for cleavage site recognition?

RA Brown, DWL Hukins, JB Weiss, TM Twose - … and biophysical research …, 1977 - Elsevier
Despite the apparent uniformity of the collagen molecule, vertebrate and invertebrate
collagenases cleave it in one region only. We suggest that the enzyme recognises the cleavage …

Process Research Towards a Scalable Synthesis of the Muscarinic M1 Receptor Subtype Selective Agonist MCD-386

…, BD Abraham, JG Farnham, TM Twose - … Process Research & …, 2011 - ACS Publications
An efficient process for the M 1 -selective muscarinic agonist MCD-386 has been developed
that offers significant advantages over the original synthetic approach. The new process …

Radioactive labelling of multiple-drug resistance factor in Escherichia coli.

GR Barker, N Hardman, TM Twose - Biochemical Journal, 1971 - ncbi.nlm.nih.gov
Substitution of D20 for H20 in aqueous media has been shown to be capable of enhancing
helical stability in DNA. polyribonucleotides and Escheri-chia coli ribosomes over certain pH …

Replication of the deoxyribonucleic acid of multiple-drug-resistance factor in Escherichia coli

GR Barker, N Hardman, TM Twose - Biochemical Journal, 1976 - portlandpress.com
1. It was shown that a system previously described for labelling R-factor DNA during transfer
to an irradiated recipient strain of Escherichia coli did not allow high selectivity in the …

[PDF][PDF] Polymorphonuclear leucocyte accumulation in inflammatory dermal sites measured by a novel neutrophil specific marker protein

DS Paterson, TM Twose, ME McCormick… - Agents and …, 1985 - academia.edu
Acute inflammation is characterized by hyperaemia, plasma exudation and polymorphonuclear
leucocyte (PMNL) accumulation. Blood flow and plasma exudation in skin can be …

[BOOK][B] Biochemical Studies on Drug Resistance in Escherichia coli

TM Twose - 1971 - search.proquest.com
… ProQuest LLC 789 East Eisenhower Parkway PO Box 1346 Ann Arbor, Ml 48106 - 1346 a
Tnesis present to the victoria univer of manchester oy trevor rn twose for the degree of doctoi …