Traditionally, both stress and depression have been associated with impaired immune function
and increased susceptibility to infectious and neoplastic disease. However over the last …

Review on the key role for activated microglia and monocytes in the pathogenesis of bipolar
disorder and schizophrenia. This review describes a key role for mononuclear phagocytes …

Idiopathic Parkinson's disease (PD) represents a complex interaction between the inherent
vulnerability of the nigrostriatal dopaminergic system, a possible genetic predisposition, and …

The isolation of a number of strains of infectious bursal disease (IBD) virus from fowl, turkeys
and ducks is described. These isolates could be grouped into two serotypes using the …

Caffeine is a member of the methylxanthine family of drugs, and is the most widely consumed
behaviourally active substance in the western world. This article is focused on the impact …

Inflammation-mediated dysregulation of the kynurenine pathway has been implicated as a
contributor to a number of major brain disorders. Consequently, we examined the impact of a …

Despite a vast amount of research into the actions of cytokines within the central nervous
system, the pharmacological role and/or physiological function of the various cytokines within …

In this study we characterised the ability of the viral mimetic poly I:C to induce a neuroinflammatory
response and induce symptoms of depression and anxiety in rats. Furthermore, the …

Neuroplasticity may have a core role in the pathophysiology of major depressive disorder (MDD),
a concept supported by experimental studies that found that excessive cortisol …

The problem of antidepressant-resistant depression has necessitated finding ways of
augmenting the actions of currently existing antidepressants. The present studies investigate the …