Certain neurosteroids rapidly alter the excitability of neurons, in part by potentiating gamma-aminobutyric
acid (GABA)-evoked chloride currents, and, like other GABA potentiating drugs…

Several structurally related metabolites of progesterone (3α-hydroxy pregnane-20-ones)
and deoxycorticosterone (3α-hydroxy pregnane-21-diol-20-ones) and their 3β-epimers were …

Progesterone is an effective anticonvulsant against pentylenetetrazol (PTZ) seizures. This
action is hypothesized to require the metabolic conversion of progesterone to the γ-…

GABA-potentiating neuroactive steroids such as pregnanolone have potent protective effects
in the pentylenetetrazol seizure test. We sought to determine if tolerance develops to the …

Pregnenolone sulfate (PS) is an endogenous neurosteroid known to antagonize GABA A
receptor-mediated inhibitory responses and potentiate NMDA receptor-mediated excitatory …

Ibogaine is an hallucinogenic indole alkaloid claimed to have anti-addictive properties.
Although its mechanism of action is unknown, binding studies have indicated that the drug may …

The scorpion venom peptide toxins tityustoxin-Kα (TsTx-Kα) and pandinustoxin-Kα (PiTx-Kα)
are novel, highly potent and selective blockers of voltage-activated K + channels. PiTx-Kα …

We confirmed that the effects of inhibitors of nitric oxide (NO) synthase, such as N ω -nitro-l-arginine
methyl ester and N G -nitro-l-arginine, differ depending on several experimental …

ADCI (5‐aminocarbonyl‐10, 11‐dihydro‐5H‐dibenzo[a, d] cyclohepten‐5,10‐imine), a low‐affinity
uncompetitive N‐methyl‐d‐aspartate (NMDA) antagonist, is a broad‐spectrum …

The effects of adenosine 3',5'-cyclic monophosphate (cAMP) and guanosine 3',5'-cyclic
monophosphate (cGMP) on slow calcium currents (ICa) were investigated using the Vaseline-…