User profiles for T. A. Brooks

Tracy A Brooks

Verified email at binghamton.edu
Cited by 3191

Making sense of G‐quadruplex and i‐motif functions in oncogene promoters

TA Brooks, S Kendrick, L Hurley - The FEBS journal, 2010 - Wiley Online Library
… All of these variations, detailed in Brooks and Hurley [10] for the G-quadruplexes of cancer,
lead to the formation of 3D structures with distinctive binding pockets that offer sites for …

Private acts and public objects: An investigation of citer motivations

TA Brooks - Journal of the American Society for Information …, 1985 - Wiley Online Library
Citation analysis has been used as a method for evaluating scholars and their impact. Evaluative
citation analysis has been employed without a clear understanding of why authors give …

Evidence of complex citer motivations

TA Brooks - Journal of the American Society for Information …, 1986 - Wiley Online Library
There were 20 scholars interviewed about their citation motives in recently published articles.
Their 437 citations were scaled along 1 or more of the following 7 citer motives: currency, …

Targeting MYC expression through G-quadruplexes

TA Brooks, LH Hurley - Genes & cancer, 2010 - journals.sagepub.com
… Reprinted from Brooks et al. with permission of the publisher. … Brooks declares no conflicts
of interest with respect to the … Brooks TA, Hurley LH. The role of supercoiling in transcriptional …

The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics

TA Brooks, LH Hurley - Nature Reviews Cancer, 2009 - nature.com
MYC is deregulated in most tumour types, but an effective means to selectively target its
aberrant expression is not yet available. Supercoiling that is induced by transcription has been …

[HTML][HTML] Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex

…, FL Danford, V Gokhale, LH Hurley, TA Brooks - Journal of Biological …, 2011 - ASBMB
Most transcription of the MYC proto-oncogene initiates in the near upstream promoter,
within which lies the nuclease hypersensitive element (NHE) III 1 region containing the CT-…

Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations

TA Brooks, BT Hawkins, JD Huber… - American Journal …, 2005 - journals.physiology.org
The blood-brain barrier (BBB) maintains brain homeostasis by limiting entry of substances to
the central nervous system through interaction of transmembrane and intracellular proteins …

Genetic and Biochemical Analysis of Mutacin 1140, a Lantibiotic from Streptococcus mutans

…, J Novák, E Sagura, JA Gutierrez, TA Brooks… - Infection and …, 1998 - Am Soc Microbiol
Streptococcus mutans JH1000 and its derivatives were previously shown (JD Hillman, KP
Johnson, and BI Yaphe, Infect. Immun. 44:141–144, 1984) to produce a low-molecular-weight, …

Construction and Characterization of an Effector Strain of Streptococcus mutans for Replacement Therapy of Dental Caries

JD Hillman, TA Brooks, SM Michalek… - Infection and …, 2000 - Am Soc Microbiol
An effector strain has been constructed for use in the replacement therapy of dental caries.
Recombinant DNA methods were used to make theStreptococcus mutans supercolonizing …

The physiological and behavioral response of pigs castrated with and without anesthesia or analgesia

MA Sutherland, BL Davis, TA Brooks… - Journal of Animal …, 2012 - academic.oup.com
Surgical castration is a common management practice performed on male pigs to prevent
the occurrence of boar taint. Surgical castration is known to cause physiological and …