Familial Hypertrophic Cardiomyopathy-Linked Mutant Troponin T Causes Stress-Induced Ventricular Tachycardia and Ca2+-Dependent Action Potential Remodeling

BC Knollmann, P Kirchhof, SG Sirenko… - Circulation …, 2003 - Am Heart Assoc
The cardiac troponin T (TnT) I79N mutation has been linked to familial hypertrophic cardiomyopathy
and high incidence of sudden death, despite causing little or no cardiac hypertrophy …

Action potential characterization in intact mouse heart: steady-state cycle length dependence and electrical restitution

…, T Schober, AO Petersen, SG Sirenko… - American Journal …, 2007 - journals.physiology.org
Transgenic mice have been increasingly utilized to investigate the molecular mechanisms
of cardiac arrhythmias, yet the rate dependence of the murine action potential duration and …

[PDF][PDF] Synchronization of stochastic Ca2+ release units creates a rhythmic Ca2+ clock in cardiac pacemaker cells

…, VA Maltsev, M Mikheev, LA Maltseva, SG Sirenko… - Biophysical journal, 2011 - cell.com
In sinoatrial node cells of the heart, beating rate is controlled, in part, by local Ca 2+
releases (LCRs) from the sarcoplasmic reticulum, which couple to the action potential via …

[HTML][HTML] F110I and R278C troponin T mutations that cause familial hypertrophic cardiomyopathy affect muscle contraction in transgenic mice and reconstituted human …

…, M Bell, J Zhao, SG Sirenko, Z Diaz, G Guzman… - Journal of Biological …, 2005 - ASBMB
We have studied the physiological effects of the troponin T (TnT) F110I and R278C mutations
associated with familial hypertrophic cardiomyopathy (FHC) in humans. Three to four-…

Ca2+/calmodulin-activated phosphodiesterase 1A is highly expressed in rabbit cardiac sinoatrial nodal cells and regulates pacemaker function

…, KV Tarasov, DR Riordon, J Lee, SG Sirenko… - Journal of molecular and …, 2016 - Elsevier
Constitutive Ca 2 + /calmodulin (CaM)-activation of adenylyl cyclases (ACs) types 1 and 8 in
sinoatrial nodal cells (SANC) generates cAMP within lipid-raft-rich microdomains to initiate …

Rhythmic beating of stem cell-derived cardiac cells requires dynamic coupling of electrophysiology and Ca cycling

I Zahanich, SG Sirenko, LA Maltseva… - Journal of molecular and …, 2011 - Elsevier
There is an intense interest in differentiating embryonic stem cells to engineer biological
pacemakers as an alternative to electronic pacemakers for patients with cardiac pacemaker …

Differential effect of troponin T mutations on the inotropic responsiveness of mouse hearts – role of myofilament Ca2+ sensitivity increase

SG Sirenko, JD Potter… - The Journal of physiology, 2006 - Wiley Online Library
Troponin T (TnT) mutations that cause familial hypertrophic cardiomyopathy (FHC) and sudden
cardiac death frequently increase myofilament Ca 2+ sensitivity, suggesting that their Ca …

Electrochemical Na+ and Ca2+ gradients drive coupled-clock regulation of automaticity of isolated rabbit sinoatrial nodal pacemaker cells

SG Sirenko, VA Maltsev, Y Yaniv… - American Journal …, 2016 - journals.physiology.org
Electrochemical Na+ and Ca2+ gradients drive coupled-clock regulation of automaticity of
isolated rabbit sinoatrial nodal pacemaker cells | American Journal of Physiology-Heart and …

Targeted point mutagenesis of mouse Kcnq1: phenotypic analysis of mice with point mutations that cause Romano-Ward syndrome in humans

…, EN Yamoah, L Nie, JC Vary Jr, SG Sirenko… - Genomics, 2004 - Elsevier
Inherited long QT syndrome is most frequently associated with mutations in KCNQ1, which
encodes the primary subunit of a potassium channel. Patients with mutations in KCNQ1 may …

Microelectrode study of the genesis of the monophasic action potential by contact electrode technique

BC Knollmann, J Tranquillo, SG Sirenko… - Journal of …, 2002 - Wiley Online Library
Monophasic Action Potential Genesis. Introduction: Despite widespread use of the contact
electrode for recording monophasic action potentials (MAPs) in both clinical and experimental …