Changes in mACh, NMDA and GABAA receptor binding after lateral fluid‐percussion injury: in vitro autoradiography of rat brain frozen sections

S Sihver, N Marklund, L Hillered… - Journal of …, 2001 - Wiley Online Library
Adult rats were subjected to a moderate lateral fluid percussion injury (FPI), followed by survival
periods of 2 and 12 h. Regional NMDA subtype glutamate, muscarinic acetylcholine and …

Effect of traumatic brain injury and nitrone radical scavengers on relative changes in regional cerebral blood flow and glucose uptake in rats

N Marklund, S Sihver, B Långström… - Journal of …, 2002 - liebertpub.com
Changes in regional cerebral blood flow (rCBF) and glucose metabolism are commonly
associated with traumatic brain injury (TBI). Reactive oxygen species (ROS) have been …

Methodological aspects for in vitro characterization of receptor binding using 11C-labeled receptor ligands: a detailed study with the benzodiazepine receptor …

W Sihver, S Sihver, M Bergström, T Murata… - Nuclear medicine and …, 1997 - Elsevier
As a complement to in vivo studies with positron emission tomography (PET), it is desirable
to perform in vitro characterization of newly developed 11 C tracers. In this report we …

Receptor imaging technique with 11C-labeled receptor ligands in living brain slices: its application to time-resolved imaging and saturation analysis of …

…, M Bergström, H Takechi, S Sihver, W Sihver… - Neuroscience …, 1996 - Elsevier
Recently we developed a novel imaging technique using positron emitter-labeled compounds
as probes and a storage phosphor screen as a detector. This approach makes it possible …

Increased Cerebral Uptake of [18F]Fluoro-Deoxyglucose but not [1-14C]Glucose Early following Traumatic Brain Injury in Rats

N Marklund, S Sihver, DA Hovda… - Journal of …, 2009 - liebertpub.com
Following experimental and clinical traumatic brain injury (TBI), the local cerebral metabolic
rate of glucose (lCMR Glc ) is commonly estimated using the 2-[ 18 F]fluoro-2-deoxy-D-…

Quantitative Autoradiography with Short-Lived Positron Emission Tomography Tracers: A Study on Muscarinic Acetylcholine Receptors withN-[11C] methyl-4 …

S Sihver, W Sihver, M Bergström, AU Höglund… - … of Pharmacology and …, 1999 - ASPET
The present work demonstrates quantitative autoradiography by using positron emission
tomography tracers and storage phosphorimaging plates. The uptake and association of [ 11 C]…

Synthesis of a 11C‐labelled derivative of the N‐methyl‐D‐aspartate receptor antagonist MK‐801

Y Andersson, N Tyrefors, S Sihver… - Journal of Labelled …, 1998 - Wiley Online Library
A one‐pot synthesis of (+)‐3‐[ 11 C]cyano‐MK‐801 was performed using a palladium‐promoted
reaction of hydrogen [ 11 C]cyanide with (+)‐3‐iodo‐MK‐801. The synthesis time was …

Development of in vitro and ex vivo positron-emitting tracer techniques and their application to neurotrauma

S Sihver - 2000 - diva-portal.org
The use of positron-emitting tracers has been extended beyond tomographic facilities in the
last few years, giving rise to a general positron-emitting tracing technique. The …

Novel Tumor Pretargeting System Based on Complementary l-Configured Oligonucleotides

…, R Bergmann, C Förster, W Sihver… - Bioconjugate …, 2017 - ACS Publications
Unnatural mirror image l-configured oligonucleotides (L-ONs) are a convenient substance
class for the application as complementary in vivo recognition system between a tumor …

The role of reactive oxygen species in traumatic brain injury: Experimental studies in the rat

N Marklund - 2001 - diva-portal.org
Marklund, N. 2001. The role of reactive oxygen species in traumatic brain injury. Experimental
studies in the rat. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala …