… Tetsuya Terasaki and Sumio Ohtsuki are a full professor and an associate professor of
Tohoku University, respectively, and are also directors of Proteomedix Frontiers. This research …

The blood–brain barrier (BBB) forms an interface between the circulating blood and the brain
and possesses various carrier-mediated transport systems for small molecules to support …

Purpose To develop an absolute quantification method for membrane proteins, and to
construct a quantitative atlas of membrane transporter proteins in the blood–brain barrier, liver …

The purpose of the present study was to determine the absolute protein expression levels of
multiple drug-metabolizing enzymes and transporters in 17 human liver biopsies, and to …

Although tight‐junctions (TJs) at the blood–brain barrier (BBB) are important to prevent non‐specific
entry of compounds into the CNS, molecular mechanisms regulating TJ …

Quantitative proteomics employing mass spectrometry is an indispensable tool in life science
research. Targeted proteomics has emerged as a powerful approach for reproducible …

We have investigated the transcriptomic and/or proteomic patterns of 71 solute carrier (SLC)
and organic solute (OST) transporters, 34 ATP-binding cassette (ABC) transporters, and 51 …

Renal impairment is associated with CNS dysfunctions and the accumulation of uremic
toxins, such as indoxyl sulfate, in blood. To evaluate the relevance of indoxyl sulfate to CNS …

Cynomolgus monkey has been used as a model for the prediction of drug disposition in
human brain. The purpose of this study was to clarify protein expression levels of membrane …

The purpose of this study was to determine the protein amounts of blood–brain barrier (BBB)
permeability-related transporters, receptors, and tight junction proteins in Sprague Dawley …