… Grigorenko, N. Boulghassoul-Pietrzykowska, and members of the Treistman laboratory for
stimulating discussions and valuable comments; S. Baker for help with statistical analysis; D. …

The activity of large conductance, Ca 2 + -sensitive K + (BK Ca ) channels, known to control
neuronal excitability, is increased by ethanol (EtOH) exposure. Moreover, brain cholesterol (…

Enhanced acute tolerance predicts alcohol abuse. We describe work on the role of the
calcium- and voltage-gated BK channel in alcohol tolerance, highlighting the lipid environment, …

The NMDA receptor/channel has been shown to be inhibited by ethanol in the clinically
relevant range 25–100 mM. We studied heteromeric assemblies (NR1b/NR2) of the NMDA …

Ethanol (EtOH) reversibly activates large conductance, Ca ++ -activated K + (BK) channels
in rat neurohypophysial terminals, an effect that probably contributes to the inhibition of …

Large conductance, Ca2-activated K channels are believed to underlie interburst intervals
and, thus, contribute to the control of hormone release from neurohypophysial terminals. …

Ingestion of ethanol results in a decreased level of plasma vasopressin, which appears to
be caused by inhibition of arginine vasopressin (AVP) release from the neurohypophysis. …

Tolerance, described as the loss of drug effectiveness over time, is an important component
of addiction. The degree of acute behavioral tolerance to alcohol exhibited by a naïve …

Transmembrane segments of ion channels tend to match the hydrophobic thickness of lipid
bilayers to minimize mismatch energy and to maintain their proper organization and function. …

Tolerance is an important element of drug addiction and provides a model for understanding
neuronal plasticity. The hypothalamic–neurohypophysial system (HNS) is an established …