The purpose of this study was to establish bupropion (BUP) hydroxylation as a selective in
vitro marker of cytochrome P450 (CYP) 2B6 catalytic activity. Among a panel of 16 human …

Both the human pregnane X receptor (hPXR) and constitutive androstane receptor (hCAR)
are capable of regulating CYP3A4 and CYP2B6 gene expression. However, the majority of …

The objectives of this study were to evaluate the ability of 14 compounds, which differentially
activate human pregnane X receptor (hPXR), to induce CYP2B6 expression and to …

Accumulated evidence suggests that cross-talk between the pregnane X receptor (PXR)
and the constitutive androstane receptor (CAR) results in shared transcriptional activation of …

Although the glucocorticoid receptor (GR) facilitates the xenobiotic-induced expression of
CYP2B in rodents, its role in the regulation of human CYP2B6 is unclear. In this report, the role …

The purpose of this investigation was to evaluate the role of cytochrome P450 (CYP) 3A4 in
human liver microsomal bupropion (BUP) hydroxylation. Across the BUP concentration …

Purpose Gemcitabine administered at a fixed dose rate of 10 mg/m 2 per min has been reported
to achieve plasma steady-state concentrations ranging from 10 to 20 μM in patients with …

The primary objective of this study was to evaluate the modulation of UGT1A1 expression in
human hepatocytes using prototypical CYP450 inducers. A bank of 16 human livers was …

In response to chemical stimuli, pregnane X receptor (PXR) and constitutive androstane
receptor (CAR) mediate transcriptional activation of an overlapping set of genes involved in …

Aim: C1-INH-HAE is caused by activation of plasma kallikrein which subsequently cleaves
high-molecular-weight kininogen (HMWK) to generate bradykinin and cHMWK. Materials & …