Numerous studies suggest that the majority of amyloid-β (Aβ) peptides deposited in Alzheimer’s
disease (AD) are truncated and post-translationally modified at the N terminus. Among …

The properties of hundreds of interplanetary particles have been determined by direct
laboratory analysis of recovered samples. The particles that span the 1 μm to 1 mm size range …

Huntington’s disease is known to be a purely genetic disease based on an expansion of a
CAG base triplet repeat in the coding region of the Huntingtin gene. Some years ago, …

Models for HD Page 1 hypothalamic injections of the excitotoxin quinolinic acid was moreover
evaluated in the same HD mouse models. Results We detected changes in mRNA levels …

Models of HD Page 1 from fluorometric cell viability assays indicated that STHdhQ111/ 111
cells had reduced cell viability and increased cell mortality. This was not supported by the …

RESULTS Contact: Roland Rabl I Preclinical Research Associate I QPS Austria GmbH I
Parkring 12 I 8074 Grambach I Austria I roland. rabl@ qps. com I www. qpsneuro. com Alzheimer…

Background The human glutaminyl cyclase (hQC) is elevated in neuronal cells and
recentreports associate pyroglutamyl peptides (pGlu Aß) with pathophysiological processes like …

Background N-terminally truncated and pyroglutamated (pGlu, pE) beta-amyloid peptides
are abundant in human sporadic and inherited Alzheimer's disease (AD). Formation of pE at …

INTRODUCTION Genetic interactions occur when mutations in two or more genes combine
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …

Time-of-flight secondary ion mass spectrometry (TOF-SIMS) was introduced into
cosmochemistry about a decade ago. Major advantages of TOF-SIMS compared to other ion …