Stoffenmanager Nano (version 1.0) is a risk-banding tool developed for employers and
employees to prioritize health risks occurring as a result of exposure to manufactured nano …

Single-chain alkylphospholipids, unlike conventional chemotherapeutic drugs, act on cell
membranes to induce apoptosis in tumor cells. We tested four different alkylphospholipids, ie, …

Concurrent treatment with radiotherapy and chemotherapy has emerged as an effective
strategy to improve clinical outcome of cancer. In addition to combining radiation with classical …

Clinical use of anti-cancer alkylphospholipids is limited by gastrointestinal toxicity. However,
new interest has emerged since it was shown that these drugs enhance the cytotoxic effect …

PURPOSE: Perifosine is an orally applicable, membrane-targeted alkylphosphocholine
analogue with antitumour activity and radiosensitising properties in preclinical models. The …

For amphiphilic anticancer drugs, such as the anthracyclin doxorubicin (Dox), uptake by
tumor cells involves slow diffusion across the plasma membrane, a limiting factor in clinical …

Purpose: Combined modality treatment has improved outcome in various solid tumors.
Besides classic anticancer drugs, a new generation of biological response modifiers has …

Perifosine is a member of the class of synthetic alkylphospholipids (APLs) and is being
evaluated as anti-cancer agent in several clinical trials. These single-chain APLs accumulate in …

BACKGROUND AND PURPOSE: Resistance to apoptosis is a contributing factor in the
response to radiotherapy. Aim of this study was to evaluate whether TRAIL – in a soluble …

The anticancer agent doxorubicin is in certain cases administered as a long-circulating
liposomal formulation. Due to angiogenesis-related structural abnormalities in the endothelial …