The abuse of psychoactive ‘bath salts’ containing cathinones such as 3, 4-methylenedioxypyrovalerone
(MDPV) is a growing public health concern, yet little is known about their …

1 The cardiovascular effects of the adenosine A 1 receptor agonist N 6 ‐cyclopentyladenosine
(CPA) and the adenosine A 2A receptor agonist 2‐p‐(2‐carboxyethyl)phenethylamino‐5…

The dopamine (DA) transporter is thought to be the primary mediator of reinforcing effects of
cocaine. In the present study, an intravenous drug self-administration procedure, in …

Inhibition of dopamine (DA) transporter function is thought to be the principal mechanism
underlying cocaine’s addictive effects. In contrast to cocaine, several other inhibitors of DA …

Background and Purpose The cardiovascular effects produced by 3,4‐methylenedioxymethamphetamine
( MDMA ; ‘ E cstasy’) contribute to its acute toxicity, but the potential role of its …

The squirrel monkey is a reliable model for the cardiovascular effects of cocaine in that it
mimics the human response to cocaine; low to moderate doses of cocaine produce a sustained …

A novel, fairly potent dopamine transporter (DAT) inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl
4-methylphenyl ketone (3, K i values of 492 and 360 nM in binding affinity …

In conscious rats, continuous iv infusion of cocaine (2 mg/kg/min) produced a marked increase
in blood pressure, an initial moderate increase followed by a decrease in heart rate, tonic-…

The objectives of this study were to investigate behavioral sensitization to repeated once
daily IV injections of cocaine, and to determine whether dopamine receptor antagonists …

Compounds with novel or fentanyl-like structures continue to appear on the illicit drug market
and have been responsible for fatalities, yet there are limited preclinical pharmacological …