[HTML][HTML] Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding
DS Daniels, CD Mol, AS Arvai, S Kanugula… - The EMBO …, 2000 - embopress.org
Human O 6-alkylguanine-DNA alkyltransferase (AGT), which directly reverses endogenous
alkylation at the O 6-position of guanine, confers resistance to alkylation chemotherapies …
alkylation at the O 6-position of guanine, confers resistance to alkylation chemotherapies …
Flipping of alkylated DNA damage bridges base and nucleotide excision repair
JL Tubbs, V Latypov, S Kanugula, A Butt, M Melikishvili… - Nature, 2009 - nature.com
Alkyltransferase-like proteins (ATLs) share functional motifs with the cancer chemotherapy
target O 6 -alkylguanine-DNA alkyltransferase (AGT) and paradoxically protect cells from the …
target O 6 -alkylguanine-DNA alkyltransferase (AGT) and paradoxically protect cells from the …
Inactivation and Degradation of O6-Alkylguanine-DNA Alkyltransferase after Reaction with Nitric Oxide
L Liu, M Xu-Welliver, S Kanugula, AE Pegg - Cancer research, 2002 - AACR
O 6 -Alkylguanine-DNA alkyltransferase (AGT) plays a critical role in protection from the
carcinogenic effects of simple alkylating agents by repairing O 6 -alkylguanine adducts via a …
carcinogenic effects of simple alkylating agents by repairing O 6 -alkylguanine adducts via a …
8-Substituted O6-benzylguanine, substituted 6 (4)-(benzyloxy) pyrimidine, and related derivatives as inactivators of human O6-alkylguanine-DNA alkyltransferase
MY Chae, K Swenn, S Kanugula… - Journal of medicinal …, 1995 - ACS Publications
Several 8-substituted 06-benzylguanines, 2-and/or 8-substituted 6-(benzyloxy) purines, sub-stituted
6 (4)-(benzyloxy) pyrimidines, and a 6-(benzyloxy)-s-triazine were tested for their …
6 (4)-(benzyloxy) pyrimidines, and a 6-(benzyloxy)-s-triazine were tested for their …
Function of Domains of Human O6-Alkylguanine-DNA Alkyltransferase
Q Fang, S Kanugula, AE Pegg - Biochemistry, 2005 - ACS Publications
O 6 -Alkylguanine-DNA alkyltransferase (AGT) is an important DNA repair protein that
protects from alkylating agents by converting O 6 -alkylguanine to guanine forming S-…
protects from alkylating agents by converting O 6 -alkylguanine to guanine forming S-…
Isolation of Human O6-Alkylguanine-DNA Alkyltransferase Mutants Highly Resistant to Inactivation by O6-Benzylguanine
M Xu-Welliver, S Kanugula, AE Pegg - Cancer research, 1998 - AACR
The activity of O 6 -alkylguanine-DNA alkyltransferase (AGT) protects cells from killing by
methylating or chloroethylating agents. AGT is strongly inhibited by O 6 -benzylguanine (ED 50 …
methylating or chloroethylating agents. AGT is strongly inhibited by O 6 -benzylguanine (ED 50 …
The Repair of the Tobacco Specific Nitrosamine Derived Adduct O6-[4-Oxo-4-(3-pyridyl)butyl]guanine by O6-Alkylguanine-DNA Alkyltransferase Variants
…, GT Pauly, RC Moschel, S Kanugula… - Chemical research in …, 2004 - ACS Publications
The tobacco specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a
potent pulmonary carcinogen, both methylates and pyridyloxobutylates DNA. Both reaction …
potent pulmonary carcinogen, both methylates and pyridyloxobutylates DNA. Both reaction …
Resistance-Modifying Agents. 8. Inhibition of O6-Alkylguanine-DNA Alkyltransferase by O6-Alkenyl-, O6-Cycloalkenyl-, and O6-(2-Oxoalkyl)guanines and Potentiation of Temozolomide …
…, NJ Curtin, C Dalby, S Kanugula… - Journal of medicinal …, 2000 - ACS Publications
A series of O 6 -allyl- and O 6 -(2-oxoalkyl)guanines were synthesized and evaluated, in
comparison with the corresponding O 6 -alkylguanines, as potential inhibitors of the DNA-repair …
comparison with the corresponding O 6 -alkylguanines, as potential inhibitors of the DNA-repair …
[HTML][HTML] Repair of O6-benzylguanine by the Escherichia coli Ada and Ogt and the human O6-alkylguanine-DNA alkyltransferases
K Goodtzova, S Kanugula, S Edara, GT Pauly… - Journal of Biological …, 1997 - ASBMB
O 6 -Methylguanine is removed from DNA via the transfer of the methyl group to a cysteine
acceptor site present in the DNA repair protein O 6 -alkylguanine-DNA alkyltransferase. The …
acceptor site present in the DNA repair protein O 6 -alkylguanine-DNA alkyltransferase. The …
DNA-reactive protein monoepoxides induce cell death and mutagenesis in mammalian cells
…, S Wickramaratne, M Campion, S Kanugula… - Biochemistry, 2013 - ACS Publications
Although cytotoxic alkylating agents possessing two electrophilic reactive groups are thought
to act by cross-linking cellular biomolecules, their exact mechanisms of action have not …
to act by cross-linking cellular biomolecules, their exact mechanisms of action have not …