This article reports on a symposium sponsored by the American Society for Pharmacology
and Experimental Therapeutics and held at the April 2001 Experimental Biology meeting. …

Methylphenidate is an important stimulant prescribed to treat attention-deficit hyperactivity
disorder. It has two chiral centers, but most current commercial formulations consist of the …

Capecitabine is an oral prodrug of 5-fluorouracil that is indicated for the treatment of breast
and colorectal cancers. A three-step in vivo-targeted activation process requiring …

Purpose: The purpose is to develop new analytical methods to study the expression profile
of CPT-11 carboxylesterases and topoisomerase I in colon tumor samples and understand …

Carboxylesterases belong to Phase I group of drug metabolizing enzymes. They hydrolyze
a variety of drug esters, amides, carbamates and similar structures. There are five ‘…

Carboxylesterases metabolize ester, thioester, carbamate, and amide compounds to more
soluble acid, alcohol, and amine products. They belong to a multigene family with about 50% …

Repeated maternal separation of pups from dams is often used as an early life stressor that
causes profound neurochemical and behavioral changes in the pups that persist into …

S-Nitrosoglutathione reductase (GSNOR) is an alcohol dehydrogenase involved in the
regulation of S-nitrosothiols (SNOs) in vivo. Knock-out studies in mice have shown that GSNOR …

Approximately 80% of the body vitamin A is stored in liver stellate cells with in the lipid droplets
as retinyl esters. In low vitamin A status or after liver injury, stellate cells are depleted of …

Retinyl esters are a major endogenous storage source of vitamin A in vertebrates and their
hydrolysis to retinol is a key step in the regulation of the supply of retinoids to all tissues. …