Antigen-specific CD8 + T-cell tolerance, induced by myeloid-derived suppressor cells (MDSCs),
is one of the main mechanisms of tumor escape. Using in vivo models, we show here …

Myeloid-derived suppressor cells (MDSC) play an important role in tumor escape by
suppressing T-cell responses. MDSC represent a group of cells of myeloid lineage at different …

Background The neuropathology of Parkinson's disease (PD) includes loss of dopaminergic
neurons in the substantia nigra, nitrated α-synuclein (N-α-Syn) enriched intraneuronal …

Cancer immunotherapeutic approaches induce tumor-specific immune responses, in
particular CTL responses, in many patients treated. However, such approaches are clinically …

Thioredoxin (Trx) and glutathione (GSH) systems are considered to be two major redox
systems in animal cells. They are reduced by NADPH via Trx reductase (TR) or oxidized GSH (…

Gene expression profiling of diffuse large B-cell lymphoma (DLBCL) has revealed prognostically
important subgroups: germinal center B-cell-like (GCB) DLBCL, activated B cell-like (…

Functionally altered myeloid cells play an important role in immune suppression in cancer,
in angiogenesis, and in tumor cells' invasion and metastases. Here, we report that inhibition …

OBJECTIVES: The objective of this study was to examine the association between tobacco
and alcohol dose and type and the age of onset of pancreatic adenocarcinoma (PancCa). …

Purpose: The goal of this study is to investigate the possible utility of dendritic cells (DCs)
transduced with the human full-length dominant-negative survivin for cancer immunotherapy. …

The MUC1 glycoprotein is considered a tumor antigen due to its over expression and aberrant
glycosylation in cancer tissues. The latter results in appearance of new antigenic tumor …