User profiles for Simon J. Conway

Simon Conway

Professor of Pediatrics, Indiana University School of Medicine
Verified email at iu.edu
Cited by 33570

Fate mapping analysis reveals that adult microglia derive from primitive macrophages

…, S Nandi, P See, S Gokhan, MF Mehler, SJ Conway… - Science, 2010 - science.org
Microglia are the resident macrophages of the central nervous system and are associated
with the pathogenesis of many neurodegenerative and brain inflammatory diseases; however, …

Prevention of allogeneic fetal rejection by tryptophan catabolism

DH Munn, M Zhou, JT Attwood, I Bondarev, SJ Conway… - Science, 1998 - science.org
In 1953 Medawar pointed out that survival of the genetically disparate (allogeneic) mammalian
conceptus contradicts the laws of tissue transplantation. Rapid T cell–induced rejection of …

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

…, A Foley, V Vedantham, L Liu, SJ Conway, J Fu… - Nature, 2012 - nature.com
The reprogramming of adult cells into pluripotent cells or directly into alternative adult cell
types holds great promise for regenerative medicine. We reported previously that cardiac …

Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages

…, SHY Choy, M Grisotto, L Renia, SJ Conway… - Journal of Experimental …, 2012 - rupress.org
Langerhans cells (LCs) are the dendritic cells (DCs) of the epidermis, forming one of the first
hematopoietic lines of defense against skin pathogens. In contrast to other DCs, LCs arise …

Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues

…, DK Turner, T Oka, SJ Conway… - Journal of cellular …, 2007 - Wiley Online Library
Periostin is predominantly expressed in collagen‐rich fibrous connective tissues that are
subjected to constant mechanical stresses including: heart valves, tendons, perichondrium, …

Adult satellite cells and embryonic muscle progenitors have distinct genetic requirements

C Lepper, SJ Conway, CM Fan - Nature, 2009 - nature.com
Myogenic potential, survival and expansion of mammalian muscle progenitors depend on the
myogenic determinants Pax3 and Pax7 embryonically 1 , and Pax7 alone perinatally 2 , 3 , …

BMP10 is essential for maintaining cardiac growth during murine cardiogenesis

…, Z Yang, MD Schneider, KR Chien, SJ Conway… - 2004 - journals.biologists.com
During cardiogenesis, perturbation of a key transition at mid-gestation from cardiac patterning
to cardiac growth and chamber maturation often leads to diverse types of congenital heart …

Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling

…, GW Dorn, SJ Conway, BJ Aronow, J Robbins… - Circulation …, 2007 - Am Heart Assoc
The cardiac extracellular matrix is a dynamic structural support network that is both influenced
by, and a regulator of, pathological remodeling and hypertrophic growth. In response to …

SDF-1 (CXCL12) is upregulated in the ischemic penumbra following stroke: association with bone marrow cell homing to injury

…, SC Fagan, JE Carroll, SJ Conway - … of Neuropathology & …, 2004 - academic.oup.com
The chemokine stromal-derived factor-1 (SDF-1, also known as CXCL12) and its receptor
CXCR4 have been implicated in homing of stem cells to the bone marrow and the homing of …

[HTML][HTML] Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the …

…, YJ Fei, FH Leibach, J Chen, SJ Conway… - Journal of Biological …, 1998 - ASBMB
We investigated the transport of cationic neurotoxins and neurotransmitters by the potential-sensitive
organic transporter OCT3 and its steroid sensitivity using heterologous expression …