The interaction of saquinavir (soft gelatin capsule) with ketoconazole, erythromycin and rifampicin: comparison of the effect in healthy volunteers and in HIV-infected …
S Grub, H Bryson, T Goggin, E Lüdin… - European journal of clinical …, 2001 - Springer
Objective: The aim of this study was to compare the effect of ketoconazole, erythromycin and
rifampicin on the pharmacokinetics of saquinavir soft-gelatin formulation (Fortovase; FTV) in …
rifampicin on the pharmacokinetics of saquinavir soft-gelatin formulation (Fortovase; FTV) in …
Mechanisms of cyclosporine A-induced apoptosis in rat hepatocyte primary cultures
S Grub, E Persohn, WE Trommer, A Wolf - Toxicology and applied …, 2000 - Elsevier
In rat hepatocytes and isolated liver mitochondrial fractions, Cyclosporine A (CsA) is often
used as a specific inhibitor of mitochondrial Ca 2+ release and as a specific blocker of …
used as a specific inhibitor of mitochondrial Ca 2+ release and as a specific blocker of …
Pharmacokinetics and pharmacodynamics of saquinavir in pediatric patients with human immunodeficiency virus infection
S Grub, P DeLora, E Lüdin, F Duff… - Clinical …, 2002 - Wiley Online Library
Objective Our objective was to investigate the clinical pharmacologic characteristics of
saquinavir given as a soft gelatin capsule, either alone or in combination with nelfinavir, to …
saquinavir given as a soft gelatin capsule, either alone or in combination with nelfinavir, to …
Induction of Apoptosis by theO-Hydroxyethyl-d (Ser) 8-cyclosporine A Derivative SDZ IMM 125 in Rat Hepatocytes
S Grub, E Persohn, WE Trommer, A Wolf - Journal of Pharmacology and …, 2000 - ASPET
The immunosuppressive cyclosporine A derivative,O-hydroxyethyl-d(Ser) 8 -cyclosporine (SDZ
IMM 125), was examined for its ability to induce apoptosis in rat hepatocytes cultured for …
IMM 125), was examined for its ability to induce apoptosis in rat hepatocytes cultured for …
Role of antioxidants in the O-hydroxyethyl-D-(Ser) 8-cyclosporine A (SDZ IMM125)-induced apoptosis in rat hepatocytes
S Grub, WE Trommer, A Wolf - Biochemical pharmacology, 2002 - Elsevier
The mechanisms underlying the apoptotic activity of the immunosuppressive drug cyclosporine
A and its O-hydroxyethyl-d-(Ser) 8 -derivative SDZ IMM125 in rat hepatocytes are not yet …
A and its O-hydroxyethyl-d-(Ser) 8 -derivative SDZ IMM125 in rat hepatocytes are not yet …
[PDF][PDF] In vitro induction of apoptosis in rat hepatocytes by cyclosporine A
A Wolf, S Grub, E Persohn, WE TROMMER - Anales de la Real Academia …, 2000 - Citeseer
In rat hepatocytes and isolated liver mitochondrial fractions, CsA is often used as a specific
inhibitor of mitochondrial Ca2+ release and as a specific blocker of mitochondrial membrane …
inhibitor of mitochondrial Ca2+ release and as a specific blocker of mitochondrial membrane …
Lipid peroxidation-independent mechanisms of vitamin E-mediated protection against cyclosporine A-induced hepatocellular toxicity and apoptosis
S Grub, UA Boelsterli, C Trendelenburg… - Toxicology …, 2003 - Taylor & Francis
Cyclosporine A (CsA) produces oxidative stress and apoptosis in rat hepatocytes, but it is
not known whether membrane lipid peroxidation plays a role in CsA toxicity. The objective of …
not known whether membrane lipid peroxidation plays a role in CsA toxicity. The objective of …
Pharmacokinetics of saquinavir in children during long term treatment
S Grub, HL Schwarzwald, MW Kline… - The Pediatric infectious …, 2002 - journals.lww.com
This letter presents a long term follow-up of pharmacokinetic data from a study of combination
antiretroviral therapy with saquinavir soft gelatin capsules and nelfinavir in children with …
antiretroviral therapy with saquinavir soft gelatin capsules and nelfinavir in children with …
Vitamin E and Hepatic Effects of Cyclosporins
S Grub, C Trendelenburg… - The Encyclopedia of … - cabidigitallibrary.org
Huge differences exist concerning the hepatic tolerability of cyclosporins in man. The O-hydroxyethyl-D-(Ser)
8-cyclosporin A derivative SDZ IMM125, which is almost equipotent to …
8-cyclosporin A derivative SDZ IMM125, which is almost equipotent to …
[CITATION][C] Grub, Sibylle, 209 Gunawardhana, L., 141
KB Adler, HV Aposhian, F Ayala-Fierro, F Azarbayjani… - Toxicology and Applied …, 2000