We have identified a novel gene referred to asactivation-induced deaminase (AID) by subtraction
of cDNAs derived from switch-induced and uninduced murine B lymphoma CH12F3-2 …

Curcumin, a major active component of turmeric, is known to induce apoptosis in several types
of cancer cells, but little is known about its activity in chemoresistant cells. Hence, the aim …

Background Curcumin inhibits the growth of esophageal cancer cell lines; however, the
mechanism of action is not well understood. It is becoming increasingly clear that aberrant …

Cancer is the second leading cause of death in US. Despite the emergence of new, targeted
agents, and the use of various therapeutic combinations, none of the available treatment …

Acquired radiation resistance is one of the major causes of radio therapy failure and subsequent
tumor relapse. Multiple approaches have been utilized to limit the radiation resistance …

Breast cancer is the most common form of cancer diagnosed in women worldwide and the
second leading cause of cancer-related deaths in the USA. Despite the development of newer …

In the gut, tumorigenesis arises from intestinal or colonic crypt stem cells. Currently, no
definitive markers exist that reliably identify gut stem cells. Here, we used the putative stem cell …

Cyclooxygenases (COX) also known as prostaglandin (PG) synthases, are present in two
forms, COX-1 and COX-2. Whereas COX-1 is responsible for cytoprotective functions in a …

Cancer is one of the leading causes of death in the United States and accounts for
approximately 8 million deaths per year worldwide. Although there is an increasing number of …

Pancreatic cancer is an exceptionally aggressive disease in great need of more effective
therapeutic options. Epithelial–mesenchymal transition (EMT) plays a key role in cancer …