[HTML][HTML] DGAT1 expression increases heart triglyceride content but ameliorates lipotoxicity
L Liu, XJ Shi, KG Bharadwaj, S Ikeda… - Journal of biological …, 2009 - ASBMB
Intracellular lipid accumulation in the heart is associated with cardiomyopathy, yet the
precise role of triglyceride (TG) remains unclear. With exercise, wild type hearts develop …
precise role of triglyceride (TG) remains unclear. With exercise, wild type hearts develop …
Development of antibody-siRNA conjugate targeted to cardiac and skeletal muscles
…, Y Masuda, T Kamei, S Takagahara, S Ikeda… - Journal of Controlled …, 2016 - Elsevier
Despite considerable efforts to develop efficient carriers, the major target organ of short-interfering
RNAs (siRNAs) remains limited to the liver. Expanding the application outside the …
RNAs (siRNAs) remains limited to the liver. Expanding the application outside the …
Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation
…, A Lymperopoulos, S Ikeda… - American Journal …, 2011 - journals.physiology.org
Normal hearts have increased contractility in response to catecholamines. Because several
lipids activate PKCs, we hypothesized that excess cellular lipids would inhibit cardiomyocyte …
lipids activate PKCs, we hypothesized that excess cellular lipids would inhibit cardiomyocyte …
Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2)
…, F Itoh, M Kajino, T Tamura, M Kaneko, S Ikeda… - Bioorganic & medicinal …, 2008 - Elsevier
3-Metoxycarbonyl isoquinolone derivative 1 has been identified as a potent JNK inhibitor
and significantly inhibited cardiac hypertrophy in a rat pressure-overload model. Herein, a …
and significantly inhibited cardiac hypertrophy in a rat pressure-overload model. Herein, a …
Design, synthesis, and evaluation of the highly selective and potent G-protein-coupled receptor kinase 2 (GRK2) inhibitor for the potential treatment of heart failure
…, Y Toyoda, T Henta, A Hata, S Ikeda… - Journal of medicinal …, 2017 - ACS Publications
A novel class of therapeutic drug candidates for heart failure, highly potent and selective
GRK2 inhibitors, exhibit potentiation of β-adrenergic signaling in vitro studies. Hydrazone …
GRK2 inhibitors, exhibit potentiation of β-adrenergic signaling in vitro studies. Hydrazone …
[HTML][HTML] Zooxanthellal genetic varieties in giant clams are partially determined by species-intrinsic and growth-related characteristics
S Ikeda, H Yamashita, S Kondo, K Inoue, S Morishima… - PloS one, 2017 - journals.plos.org
Giant clams (tridacnine shellfishes) are large bivalves that inhabit tropical and subtropical
waters and harbor the symbiotic microalgae zooxanthellae, which consist of diverse …
waters and harbor the symbiotic microalgae zooxanthellae, which consist of diverse …
[HTML][HTML] Completion of a new accelerator-driven compact neutron source prototype RANS-II for on-site use
T Kobayashi, S Ikeda, Y Otake, Y Ikeda… - Nuclear Instruments and …, 2021 - Elsevier
RIKEN accelerator driven compact neutron source II (RANS-II), a neutron source that is
designed to serve as a prototype of a next-generation downsized accelerator-based compact …
designed to serve as a prototype of a next-generation downsized accelerator-based compact …
[HTML][HTML] A novel selective inhibitor of delta-5 desaturase lowers insulin resistance and reduces body weight in diet-induced obese C57BL/6J mice
…, YO Tamura, I Miyahisa, J Matsui, H Suzuki, S Ikeda… - PLoS …, 2016 - journals.plos.org
Obesity is now recognized as a state of chronic low-grade inflammation and is called as
metabolic inflammation. Delta-5 desaturase (D5D) is an enzyme that metabolizes dihomo-γ-…
metabolic inflammation. Delta-5 desaturase (D5D) is an enzyme that metabolizes dihomo-γ-…
Contribution of afferent renal nerve signals to acute and chronic blood pressure regulation in stroke-prone spontaneously hypertensive rats
S Ikeda, K Shinohara, S Kashihara… - Hypertension …, 2023 - nature.com
The activation of sympathetic nervous system plays a critical role in the development of
hypertension. The input from afferent renal nerves may affect central sympathetic outflow; …
hypertension. The input from afferent renal nerves may affect central sympathetic outflow; …
Neuronatin: a new inflammation gene expressed on the aortic endothelium of diabetic mice
N Mzhavia, S Yu, S Ikeda, TT Chu, I Goldberg… - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—Identification of arterial genes and pathways altered in obesity and diabetes.
RESEARCH DESIGN AND METHODS—Aortic gene expression profiles of obese and …
RESEARCH DESIGN AND METHODS—Aortic gene expression profiles of obese and …