Critical role of Rho-kinase pathway for cardiac performance and remodeling in failing rat hearts

…, S Horinaka, S Mita, S Nakano… - Cardiovascular …, 2002 - academic.oup.com
Objectives: Rho and Rho-kinase play a critical role in the regulation of cellular functions
such as proliferation and migration. To elucidate the molecular mechanisms that regulate …

Cardioprotective mechanisms of eplerenone on cardiac performance and remodeling in failing rat hearts

N Kobayashi, K Yoshida, S Nakano, T Ohno… - …, 2006 - Am Heart Assoc
Aldosterone may play a pivotal role in the pathophysiology of heart failure. To elucidate the
beneficial cardioprotective mechanism of eplerenone, a novel selective aldosterone blocker, …

Cardioprotective mechanisms of spironolactone associated with the angiotensin-converting enzyme/epidermal growth factor receptor/extracellular signal-regulated …

S Nakano, N Kobayashi, K Yoshida, T Ohno… - Hypertension …, 2005 - nature.com
Studies were performed to test the hypothesis that the angiotensin-converting enzyme (ACE)/epidermal
growth factor receptor (EGFR)/extracellular signal-regulated kinases (ERK) …

Eplerenone shows renoprotective effect by reducing LOX-1–mediated adhesion molecule, PKCε-MAPK-p90RSK, and rho-kinase pathway

…, T Honda, K Yoshida, S Mita, S Nakano… - …, 2005 - Am Heart Assoc
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) may play an important role in
atherosclerosis by inducing leukocyte adhesion molecules, such as intercellular and …

Cardioprotective mechanisms of Rho-kinase inhibition associated with eNOS and oxidative stress-LOX-1 pathway in Dahl salt-sensitive hypertensive rats

S Mita, N Kobayashi, K Yoshida, S Nakano… - Journal of …, 2005 - journals.lww.com
Objectives Rho-kinase plays a crucial role in various cellular functions. To elucidate molecular
mechanisms of Rho-kinase-mediated cardiovascular remodeling in vivo, we evaluated …

Celiprolol activates eNOS through the PI3K-Akt pathway and inhibits VCAM-1 via NF-κB induced by oxidative stress

…, T Honda, T Kobayashi, K Hara, S Nakano… - …, 2003 - Am Heart Assoc
Vascular cell adhesion molecule-1 (VCAM-1) and reactive oxygen species play critical roles
in early atherogenesis, and nitric oxide (NO) is an important regulator of the cardiovascular …

Involvement of Rho-kinase pathway for angiotensin II-induced plasminogen activator inhibitor-1 gene expression and cardiovascular remodeling in hypertensive rats

N Kobayashi, S Nakano, S Mita, T Kobayashi… - Journal of pharmacology …, 2002 - ASPET
Angiotensin II (Ang II) is a potent stimulator of plasminogen activator inhibitor-1 (PAI-1)
expression, which is an important regulator of pathogenesis of atherosclerosis. Rho-kinase, a …

Nicorandil protects against lethal ischemic ventricular arrhythmias and up-regulates endothelial nitric oxide synthase expression and sulfonylurea receptor 2 mRNA in …

…, Y Mori, Y Tsubokou, K Yoshida, S Nakano… - … drugs and therapy, 2004 - Springer
Nicorandil is an adenosine triphosphate sensitive K (K-ATP) channel opener and a nitric oxide
donor. K-ATP channels and nitric oxide are important factors in ischemic preconditioning, …

Critical role of bradykinin-eNOS and oxidative stress-LOX-1 pathway in cardiovascular remodeling under chronic angiotensin-converting enzyme inhibition

N Kobayashi, T Honda, K Yoshida, S Nakano, T Ohno… - Atherosclerosis, 2006 - Elsevier
To elucidate the molecular mechanisms of the cardioprotective effect of angiotensin-converting
enzyme (ACE) inhibitors, we evaluated whether the effect of quinapril involved in …

Celiprolol stimulates endothelial nitric oxide synthase expression and improves myocardial remodeling in deoxycorticosterone acetate-salt hypertensive rats

N Kobayashi, Y Mori, S Nakano, Y Tsubokou… - Journal of …, 2001 - journals.lww.com
Objective Endothelium-dependent vasodilation is attenuated in humans and experimental
hypertension models, and this phenomenon may be largely due to decreased release or …