Dramatic decreases in brain reward function during nicotine withdrawal

MP Epping-Jordan, SS Watkins, GF Koob, A Markou - Nature, 1998 - nature.com
Tobacco smoking is a worldwide public health problem. In the United States alone, over
400,000 deaths and $50 billion in medical costs annually are directly attributed to smoking 1 . …

Neural mechanisms underlying nicotine addiction: acute positive reinforcement and withdrawal

SS Watkins, GF Koob, A Markou - Nicotine & Tobacco Research, 2000 - academic.oup.com
The neurobiology of nicotine addiction is reviewed within the context of neurobiological and
behavioral theories postulated for other drugs of abuse. The roles of various …

Reward and somatic changes during precipitated nicotine withdrawal in rats: centrally and peripherally mediated effects

SS Watkins, L Stinus, GF Koob, A Markou - Journal of Pharmacology and …, 2000 - ASPET
The negative affective aspects of nicotine withdrawal have been hypothesized to contribute
to tobacco dependence. In the present studies in rats, brain stimulation reward thresholds, …

Blockade of nicotine self-administration with nicotinic antagonists in rats

SS Watkins, MP Epping-Jordan, GF Koob… - Pharmacology …, 1999 - Elsevier
The reinforcing properties of a variety of drugs abused by humans have been investigated
using the technique of intravenous self-administration in the rat. To examine the effect of …

[BOOK][B] Opponent process and nicotine addiction: Perpetuation of dependence through negative reinforcement processes

SS Watkins - 2000 - search.proquest.com
… The dissertation of Shelly Watkins is approved, and it is acceptable in quality and … and Shelly
Watkins contributed equally to the spontaneous withdrawal experiments and Shelly Watkins

Anti-tumor activity and trafficking of self, tumor-specific T cells against tumors located in the brain

…, H Soto, MY Yang, MS Lin, S Shelly… - Cancer Immunology …, 2008 - Springer
It is commonly believed that T cells have difficulty reaching tumors located in the brain due
to the presumed “immune privilege” of the central nervous system (CNS). Therefore, we …

Cultural and economic approaches to fertility: Proper marriage or mesalliance?

RA Pollak, SC Watkins - Population and development review, 1993 - JSTOR
Watkins (forthcoming), in a review of articles that have appeared in Demography over the
last three decades, finds emphasis on economic explanations for fertility decline. Yet the …

[PDF][PDF] THE COAL INDUSTRY AND MERCURY POLLUTION IN WEST VIRGINIA

I Chapman, S Watkins, D Gang - ilin.asee.org
Coal is an important part of the economy both in West Virginia and on the national level. In
West Virginia, the coal industry currently provides about 40,000 direct jobs, which includes …

Propagation of dendritic cell progenitors from normal mouse liver using granulocyte/macrophage colony-stimulating factor and their maturational development in the …

L Lu, J Woo, AS Rao, Y Li, SC Watkins, S Qian… - The Journal of …, 1994 - rupress.org
Within 1 wk of liquid culture in granulocyte/macrophage colony-stimulating factor (GM-CSF),
normal B10 BR (H-2k I-E+) mouse liver nonparenchymal cells (NPC) formed loosely …

Dysregulated bile transporters and impaired tight junctions during chronic liver injury in mice

…, L Molina, S Kakar, P Cornuet, M Poddar, SC Watkins… - Gastroenterology, 2018 - Elsevier
… Russell 1 5 , Sucha Singh 1 , Adeola Adebayo Michael 1 , Laura Molina 1 , Shelly Kakar
3 , Pamela Cornuet 1 , Minakshi Poddar 1 , Simon C. Watkins 4 , Kari N. Nejak-Bowen 1 5 , …