Synthesis, cytotoxicity, antiviral activity and interferon inducing ability of 6-(2-aminoethyl)-6H-indolo [2, 3-b] quinoxalines
MO Shibinskaya, SA Lyakhov, AV Mazepa… - European journal of …, 2010 - Elsevier
New 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxalines were synthesized with high yields
using bromoethylisatin and 6-(2-bromoethyl)-6H-indolo[2,3-b]quinoxaline as intermediates. …
using bromoethylisatin and 6-(2-bromoethyl)-6H-indolo[2,3-b]quinoxaline as intermediates. …
Anti-inflammatory effects and joint protection in collagen-induced arthritis after treatment with IQ-1S, a selective c-Jun N-terminal kinase inhibitor
…, I Kochetkova, AI Khlebnikov, SA Lyakhov… - … of Pharmacology and …, 2015 - ASPET
c-Jun N-terminal kinases (JNKs) participate in many physiologic and pathologic processes,
including inflammatory diseases. We recently synthesized the sodium salt of IQ-1S (11H-…
including inflammatory diseases. We recently synthesized the sodium salt of IQ-1S (11H-…
[HTML][HTML] Diet and subsistence in Bronze Age pastoral communities from the southern Russian steppes and the North Caucasus
…, VE Maslov, VG Petrenko, SV Lyakhov… - PloS one, 2020 - journals.plos.org
The flanks of the Caucasus Mountains and the steppe landscape to their north offered highly
productive grasslands for Bronze Age herders and their flocks of sheep, goat, and cattle. …
productive grasslands for Bronze Age herders and their flocks of sheep, goat, and cattle. …
Synthesis and affinity to DNA of phenylbenzoimidazoles and benzoimidazo [1, 2-c] quinazolines
…, JV Nekhoroshkova, LM Shafran, SA Lyakhov - European journal of …, 2009 - Elsevier
Novel N-(benzoimidazophenyl)dialkylaminoalkylamides and 6-dialkylaminoalkylbenzoimidazo[1,2-c]quinazolines
were prepared as potential interferon inducers and antiviral agents. …
were prepared as potential interferon inducers and antiviral agents. …
Synthesis and biological activity of 7H-benzo [4, 5] indolo [2, 3-b]-quinoxaline derivatives
MO Shibinskaya, AS Karpenko, SA Lyakhov… - European journal of …, 2011 - Elsevier
New 7-(2-aminoethyl)-7H-benzo[4,5]indolo[2,3-b]quinoxalines (13–20) were synthesized
with high yields starting from 3H-benzo[e]indole-1,2-dione. These compounds were screened …
with high yields starting from 3H-benzo[e]indole-1,2-dione. These compounds were screened …
Synthesis of 6‐Aminopropyl‐6H‐indolo [2, 3‐b] quinoxaline Derivatives
…, NA Kutuzova, AV Mazepa, SA Lyakhov… - Journal of …, 2012 - Wiley Online Library
A series of 6‐(3‐aminopropyl)‐6H‐indolo[2,3‐b]quinoxalines were synthesized with high
yields by the reaction of 6‐(3‐chloropropyl)‐6H‐indolo[2,3‐b]quinoxaline and corresponding …
yields by the reaction of 6‐(3‐chloropropyl)‐6H‐indolo[2,3‐b]quinoxaline and corresponding …
Virtual screening, synthesis and biological evaluation of DNA intercalating antiviral agents
K Klimenko, S Lyakhov, M Shibinskaya… - Bioorganic & Medicinal …, 2017 - Elsevier
This paper describes computer-aided design of new anti-viral agents against Vaccinia virus
(VACV) potentially acting as nucleic acid intercalators. Earlier obtained experimental data …
(VACV) potentially acting as nucleic acid intercalators. Earlier obtained experimental data …
[PDF][PDF] Diphenyl derivatives: cytotoxicity, antiviral and IFN-inducing activities in vitro
…, NM Zholobak, OV Dolga, GV Maltzev, SA Lyakhov… - Int. J. Biomed, 2011 - academia.edu
Background: the search for new antiviral drugs is the pressing task ahead of scientists all
over the world. Ideally, the new drugs should be less cytotoxic and act directly on the virus or …
over the world. Ideally, the new drugs should be less cytotoxic and act directly on the virus or …
Synthesis and Biological Activity of 1, 2, 3, 4-Tetrahydroindolo [2, 3-b] Quinoxaline Derivatives
…, AS Karpenko, SA Lyakhov… - Journal of …, 2015 - ingentaconnect.com
A series of novel 6-(2-aminoethyl)-1,2,3,4-tetrahydroindolo[2,3-b]quinoxalines (3a–f) was
synthesized. Members of this series were designed as nonplanar analogs of 6-(2-aminoethyl)-…
synthesized. Members of this series were designed as nonplanar analogs of 6-(2-aminoethyl)-…
Transparent dense sodium
Under pressure, metals exhibit increasingly shorter interatomic distances. Intuitively, this
response is expected to be accompanied by an increase in the widths of the valence and …
response is expected to be accompanied by an increase in the widths of the valence and …