This article provides a brief overview of the history of substance P from its discovery in the
1930s to the present day. The development of substance P receptor agonists and antagonists, …

Platinum-based anticancer drugs cause neurotoxicity. In particular, oxaliplatin produces
early-developing, painful, and cold-exacerbated paresthesias. However, the mechanism …

The endogenous cannabinoid receptor ligand, anandamide (AEA), is a full agonist of the
vanilloid receptor type 1 (VR1) for capsaicin. Here, we demonstrate that the potency and …

1 Hydrogen sulfide (H 2 S) is described as a mediator of diverse biological effects, and is
known to produce irritation and injury in the lung following inhalation. Recently, H 2 S has been …

Recently, the cannabinoid (CB) receptor agonist anandamide (AEA) has been shown to excite
perivascular terminals of primary sensory neurons via activation of the vanilloid receptor-…

Although neurokinin 1 receptor antagonists prevent ethanol (EtOH)-induced gastric lesions,
the mechanisms by which EtOH releases substance P (SP) and SP damages the mucosa …

Background: Iodo-resiniferatoxin (I-RTX) has recently been described as an ultra potent
antagonist of the transient receptor potential vanilloid-1 (TRPV1). Methods: The ability of I-RTX …

Stimulation of the vanilloid receptor‐1 (TRPV1) results in the activation of nociceptive and
neurogenic inflammatory responses. Poor specificity and potency of TRPV1 antagonists has, …

Ethanol (EtOH) stimulates peptidergic primary sensory neurons via the activation of the
transient receptor potential vanilloid-1 (TRPV1). EtOH is also known to trigger attacks of asthma …

A lowered threshold to the cough response frequently accompanies chronic airway
inflammatory conditions. However, the mechanism(s) that from chronic inflammation results in a …