Gene expression profiling is a useful tool to predict and interrogate mechanisms of toxicity.
RNA-Seq technology has emerged as an attractive alternative to traditional microarray …

Most small molecule drugs interact with unintended, often unknown, biological targets and
these off-target interactions may lead to both preclinical and clinical toxic events. Undesired off…

INTRODUCTION: General neurobehavioral assays, like a modified Irwin test or a functional
observational battery, are necessary for central nervous system (CNS) safety pharmacology …

Most pharmaceutical companies test their discovery-stage proprietary molecules in a battery
of in vitro pharmacology assays to try to determine off-target interactions. During all phases …

Acyl CoA/diacylglycerol acyltransferase (DGAT) 1 is one of two known DGAT enzymes that
catalyze the final and only committed step in triglyceride biosynthesis. The purpose of this …

The physiological responses to treadmill roller skiing with the double pole (DP) and diagonal
stride (DS) techniques were compared at 1.7% and 7.1% grades among eight cross-…

Capsaicin is an agonist of transient receptor potential vanilloid type 1 (TRPV1), in which it
can act as a neuronal stimulant and result in nociception. Capsaicin also affects a variety of …

Postprandial serum triglyceride concentrations have recently been identified as a major,
independent risk factor for future cardiovascular events. As a result, postprandial hyperlipidemia …

Previous studies have shown that the muscle chemoreflex causes an augmented blood
pressure response to exercise and partially restores blood flow to ischemic muscle. The purpose …

Renal sympathetic nerve activity (RSNA) increases abruptly at the onset of treadmill exercise
in conscious rabbits. This study investigated whether the rise in RSNA is related to the …