User profiles for Sabatino Maione

Sabatino Maione

Professore ordinario di farmacologia, Dipartimento di Medicina Sperimentale, Seconda …
Verified email at unina2.it
Cited by 14736

Forebrain pain mechanisms

V Neugebauer, V Galhardo, S Maione… - Brain research reviews, 2009 - Elsevier
Emotional–affective and cognitive dimensions of pain are less well understood than
nociceptive and nocifensive components, but the forebrain is believed to play an important role. …

[HTML][HTML] Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain

…, J Enns, M Lopez-Canul, M Aboud, S Maione… - Pain, 2019 - journals.lww.com
Clinical studies indicate that cannabidiol (CBD), the primary nonaddictive component of
cannabis that interacts with the serotonin (5-HT) 1A receptor, may possess analgesic and …

Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways …

S Maione, T Bisogno, V de Novellis, E Palazzo… - … of Pharmacology and …, 2006 - ASPET
In the ventrolateral periaqueductal gray (PAG), activation of excitatory output neurons
projecting monosynaptically to OFF cells in the rostral ventromedial medulla (RVM) causes …

Changes in spinal and supraspinal endocannabinoid levels in neuropathic rats

…, V de Novellis, T Bisogno, F Rossi, S Maione… - …, 2007 - Elsevier
Recent studies have shown that activation of the cannabinoid CB 1 receptor by synthetic
agonists, and pharmacological elevation of endocannabinoid levels, suppress hyperalgesia …

Non‐psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action

S Maione, F Piscitelli, L Gatta, D Vita… - British journal of …, 2011 - Wiley Online Library
BACKGROUND AND PURPOSE Two non‐psychoactive cannabinoids, cannabidiol (CBD)
and cannabichromene (CBC), are known to modulate in vitro the activity of proteins involved …

Analgesic actions of N‐arachidonoyl‐serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors

S Maione, L De Petrocellis… - British journal of …, 2007 - Wiley Online Library
Background and purpose: N‐arachidonoyl‐serotonin (AA‐5‐HT) is an inhibitor of fatty acid
amide hydrolase (FAAH)‐catalysed hydrolysis of the endocannabinoid/ endovanilloid …

[HTML][HTML] A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol: Δ9 …

…, F Russo, L Luongo, M Iannotta, S Maione… - Scientific reports, 2019 - nature.com
(-)-Trans-Δ 9-tetrahydrocannabinol (Δ 9-THC) is the main compound responsible for the
intoxicant activity of Cannabis sativa L. The length of the side alkyl chain influences the …

Tonic endovanilloid facilitation of glutamate release in brainstem descending antinociceptive pathways

K Starowicz, S Maione, L Cristino… - Journal of …, 2007 - Soc Neuroscience
Activation of transient receptor potential vanilloid-1 (TRPV1) channels in the periaqueductal
gray (PAG) activates OFF antinociceptive neurons of the rostral ventromedial medulla (RVM)…

The plant cannabinoid Δ9‐tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice

D Bolognini, B Costa, S Maione… - British journal of …, 2010 - Wiley Online Library
Background and purpose: The phytocannabinoid, Δ 9 ‐tetrahydrocannabivarin (THCV), can
block cannabinoid CB 1 receptors. This investigation explored its ability to activate CB 2 …

Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states

…, K Janes, T Doyle, J Xie, L Luongo, DK Tosh, S Maione… - Brain, 2015 - academic.oup.com
Chronic pain is a global burden that promotes disability and unnecessary suffering. To date,
efficacious treatment of chronic pain has not been achieved. Thus, new therapeutic targets …