User profiles for Sabatino Maione
Sabatino MaioneProfessore ordinario di farmacologia, Dipartimento di Medicina Sperimentale, Seconda … Verified email at unina2.it Cited by 14736 |
Forebrain pain mechanisms
Emotional–affective and cognitive dimensions of pain are less well understood than
nociceptive and nocifensive components, but the forebrain is believed to play an important role. …
nociceptive and nocifensive components, but the forebrain is believed to play an important role. …
[HTML][HTML] Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain
Clinical studies indicate that cannabidiol (CBD), the primary nonaddictive component of
cannabis that interacts with the serotonin (5-HT) 1A receptor, may possess analgesic and …
cannabis that interacts with the serotonin (5-HT) 1A receptor, may possess analgesic and …
Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways …
In the ventrolateral periaqueductal gray (PAG), activation of excitatory output neurons
projecting monosynaptically to OFF cells in the rostral ventromedial medulla (RVM) causes …
projecting monosynaptically to OFF cells in the rostral ventromedial medulla (RVM) causes …
Changes in spinal and supraspinal endocannabinoid levels in neuropathic rats
Recent studies have shown that activation of the cannabinoid CB 1 receptor by synthetic
agonists, and pharmacological elevation of endocannabinoid levels, suppress hyperalgesia …
agonists, and pharmacological elevation of endocannabinoid levels, suppress hyperalgesia …
Non‐psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action
S Maione, F Piscitelli, L Gatta, D Vita… - British journal of …, 2011 - Wiley Online Library
BACKGROUND AND PURPOSE Two non‐psychoactive cannabinoids, cannabidiol (CBD)
and cannabichromene (CBC), are known to modulate in vitro the activity of proteins involved …
and cannabichromene (CBC), are known to modulate in vitro the activity of proteins involved …
Analgesic actions of N‐arachidonoyl‐serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors
S Maione, L De Petrocellis… - British journal of …, 2007 - Wiley Online Library
Background and purpose: N‐arachidonoyl‐serotonin (AA‐5‐HT) is an inhibitor of fatty acid
amide hydrolase (FAAH)‐catalysed hydrolysis of the endocannabinoid/ endovanilloid …
amide hydrolase (FAAH)‐catalysed hydrolysis of the endocannabinoid/ endovanilloid …
[HTML][HTML] A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol: Δ9 …
(-)-Trans-Δ 9-tetrahydrocannabinol (Δ 9-THC) is the main compound responsible for the
intoxicant activity of Cannabis sativa L. The length of the side alkyl chain influences the …
intoxicant activity of Cannabis sativa L. The length of the side alkyl chain influences the …
Tonic endovanilloid facilitation of glutamate release in brainstem descending antinociceptive pathways
Activation of transient receptor potential vanilloid-1 (TRPV1) channels in the periaqueductal
gray (PAG) activates OFF antinociceptive neurons of the rostral ventromedial medulla (RVM)…
gray (PAG) activates OFF antinociceptive neurons of the rostral ventromedial medulla (RVM)…
The plant cannabinoid Δ9‐tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice
Background and purpose: The phytocannabinoid, Δ 9 ‐tetrahydrocannabivarin (THCV), can
block cannabinoid CB 1 receptors. This investigation explored its ability to activate CB 2 …
block cannabinoid CB 1 receptors. This investigation explored its ability to activate CB 2 …
Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states
Chronic pain is a global burden that promotes disability and unnecessary suffering. To date,
efficacious treatment of chronic pain has not been achieved. Thus, new therapeutic targets …
efficacious treatment of chronic pain has not been achieved. Thus, new therapeutic targets …