Heparanase: a rainbow pharmacological target associated to multiple pathologies including rare diseases
S Rivara, FM Milazzo, G Giannini - Future medicinal chemistry, 2016 - Future Science
… Overall, there is an intimate crosstalk between the heparanase receptor(s) and integrins …
ECM-associated HSPG can be metabolically labeled by cultured cells with [ 35 S]Na 2 SO 4 [1,…
ECM-associated HSPG can be metabolically labeled by cultured cells with [ 35 S]Na 2 SO 4 [1,…
Symptoms, complications and management of long COVID: a review
… The views expressed in this article are those of the author(s) and not necessarily those of the
… The views expressed in this article are those of the author(s) and not necessarily those of …
… The views expressed in this article are those of the author(s) and not necessarily those of …
[HTML][HTML] Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: the CONSORT-AI extension
The CONSORT 2010 statement provides minimum guidelines for reporting randomised trials.
Its widespread use has been instrumental in ensuring transparency in the evaluation of …
Its widespread use has been instrumental in ensuring transparency in the evaluation of …
Melanoma cells inhibit natural killer cell function by modulating the expression of activating receptors and cytolytic activity
Natural killer (NK) cells play a key role in tumor immune surveillance. However, adoptive
immunotherapy protocols using NK cells have shown limited clinical efficacy to date, possibly …
immunotherapy protocols using NK cells have shown limited clinical efficacy to date, possibly …
Cyclohexylcarbamic acid 3 '-or 4 '-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure− activity relationships, and …
Fatty acid amide hydrolase (FAAH) is a promising target for modulating endocannabinoid
and fatty acid ethanolamide signaling, which may have important therapeutic potential. We …
and fatty acid ethanolamide signaling, which may have important therapeutic potential. We …
Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation
… To test whether (S)-OOPP inhibits NAAA activity in intact cells we first induced a localized
inflammatory response in mice by implanting sc polyethylene sponges instilled with the …
inflammatory response in mice by implanting sc polyethylene sponges instilled with the …
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus
The functions of 2-arachidonoylglycerol (2-AG), the most abundant endocannabinoid found
in the brain, remain largely unknown. Here we show that two previously unknown inhibitors …
in the brain, remain largely unknown. Here we show that two previously unknown inhibitors …
[HTML][HTML] Clathrin-associated AP-1 controls termination of STING signalling
… The first pathway diverges along STING’s transition to the Golgi and enables autophagy,
an … The initiation of STING’s downstream transcription cascade is controlled by a multi-step …
an … The initiation of STING’s downstream transcription cascade is controlled by a multi-step …
MT1 and MT2 Melatonin Receptors: Ligands, Models, Oligomers, and Therapeutic Potential
… affinity agonist BI-167107 and the G s protein with β2AR structures obtained in the presence
… G s protein in its inactive and active state, the authors showed that the presence of the G s …
… G s protein in its inactive and active state, the authors showed that the presence of the G s …
Design, synthesis, and structure− activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors
…, S Rivara, PV Plazzi, C Park, S Kathuria… - Journal of medicinal …, 2003 - ACS Publications
… Furthermore, replacement of oxygen with sulfur (compounds 16b−d, 18) also led to inactive
analogues, with the partial exception of the thiocarbamic acid S-naphthyl ester 16b. These …
analogues, with the partial exception of the thiocarbamic acid S-naphthyl ester 16b. These …