Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota
…, KT Chen, AK Moss, S Ramasamy, A Faruqui, S Hodin… - Gut, 2010 - gut.bmj.com
Background and aims The intestinal microbiota plays a critical role in maintaining human
health; however, the mechanisms governing the normal homeostatic number and composition …
health; however, the mechanisms governing the normal homeostatic number and composition …
In vitro comparison of the role of P-glycoprotein and breast cancer resistance protein on direct oral anticoagulants disposition
S Hodin, T Basset, E Jacqueroux, O Delezay… - European journal of …, 2018 - Springer
… balanced salt solution (HBSS), Dulbecco’s phosphate buffered saline without sodium
and magnesium (DPBS), HEPES buffer, heat-inactivated fetal bovine serum (FBS), trypsin, …
and magnesium (DPBS), HEPES buffer, heat-inactivated fetal bovine serum (FBS), trypsin, …
Pharmacological characterization of the 3D MucilAir™ nasal model
…, E Jacqueroux, Z He, S Hodin, S Constant… - European Journal of …, 2019 - Elsevier
The preclinical evaluation of nasally administered drug candidates requires screening studies
based on in vitro models of the nasal mucosa. The aim of this study was to evaluate the …
based on in vitro models of the nasal mucosa. The aim of this study was to evaluate the …
Assessment of HBEC-5i endothelial cell line cultivated in astrocyte conditioned medium as a human blood-brain barrier model for ABC drug transport studies
… 1) P app = V r C 0 × 1 S × C 1 t where P app is the apparent … in the donor chamber at T 0
, S is the surface area of the … We found a permeability value of 67.0 ± 4.4 × 10 −6 cm.s −1 . …
, S is the surface area of the … We found a permeability value of 67.0 ± 4.4 × 10 −6 cm.s −1 . …
Pharmacokinetic/pharmacodynamic model for unfractionated heparin dosing during cardiopulmonary bypass
…, F Sandri, J Lanoiselée, S Hodin… - BJA: British Journal …, 2017 - academic.oup.com
Background. High-dose heparin is used during cardiopulmonary bypass (CPB) to prevent
thrombosis in the circuits used for extracorporeal circulation. The aim of this study was, initially…
thrombosis in the circuits used for extracorporeal circulation. The aim of this study was, initially…
Effect of activated charcoal on rivaroxaban complex absorption
…, S Hodin, J Lanoiselée, J Escal, S Accassat… - Clinical …, 2017 - Springer
… With regard to laboratory data, the median activated partial thromboplastin time (range)
was 1.01 (0.96–1.1) s, median plasma fibrinogen concentration was 2.45 (1.8–3.2) g/L and …
was 1.01 (0.96–1.1) s, median plasma fibrinogen concentration was 2.45 (1.8–3.2) g/L and …
In vitro and in vivo evaluation of drug–drug interaction between dabigatran and proton pump inhibitors
… TEER was computed according to the formula: (R i - R b ) × S where R i is the measured
resistance in the insert, R b is the measured resistance in a blank insert, and S is the area of the …
resistance in the insert, R b is the measured resistance in a blank insert, and S is the area of the …
In vitro assessment of P‐gp and BCRP transporter‐mediated drug–drug interactions of riociguat with direct oral anticoagulants
…, V Margelidon‐Cozzolino, S Hodin… - Fundamental & …, 2020 - Wiley Online Library
… Pharmacokinetics of riociguat and DOAC s are influenced by … drug interactions of riociguat
with DOAC s using in vitro models. … of BCRP ‐mediated DOAC s transport by riociguat. In vivo …
with DOAC s using in vitro models. … of BCRP ‐mediated DOAC s transport by riociguat. In vivo …
In vitro assessment of pharmacokinetic drug-drug interactions of direct oral anticoagulants: type 5-phosphodiesterase inhibitors are inhibitors of rivaroxaban and …
V Margelidon-Cozzolino, S Hodin, E Jacqueroux… - … of Pharmacology and …, 2018 - ASPET
… passage 27, containing Dulbecco’s modified Eagle’s medium supplemented with 10% fetal
… in the blank insert (nonseeded insert), and S is the area of the cell monolayer (0.3 cm 2 ). …
… in the blank insert (nonseeded insert), and S is the area of the cell monolayer (0.3 cm 2 ). …
[HTML][HTML] Population pharmacokinetic model of cefazolin in total hip arthroplasty
J Lanoiselée, R Chaux, S Hodin, S Bourayou… - Scientific reports, 2021 - nature.com
Cefazolin is an antibiotic recommended for infection prevention in total hip arthroplasty (THA).
However, the dosing regimen necessary to achieve therapeutic concentrations in obese …
However, the dosing regimen necessary to achieve therapeutic concentrations in obese …