… A newer compound, IPS 539, was introduced as a potent and highly selective antagonist (2),
but this compound was not very selective when examined in our laboratory (O'Donnell and …

4‐Hydroxypropranolol, a metabolite produced after oral administration of propranolol, has
been shown to be a β‐adrenoceptor blocking drug. It is of similar potency to propranolol in …

1. pA2 values have been obtained for propranolol, butoxamine, H35/25 and atenolol on
guinea-pig isolated trachea and atria (rate) using noredrenaline (beta 1-selective), isoprenaline (…

… Data obtained with procaterol on blood vessels in the present study and in a previous study
(O'Donnell & Wanstall, 1984a) have illustrated the high degree of P2: Pl selectivity of this …

Rat pulmonary artery contains both alpha adrenoceptors mediating contraction and beta-1
and beta-2 adrenoceptors mediating relaxation. Neither alpha nor beta adrenoceptor-…

… (O'Donnell, 1970… SR O'Donnell, 1967, The interaction of cocaine and propranolol with
catecholamines on guineapig trachea, European J. Pharmacol. 2, 77. Chahl, LA, and SR O'Donnell…

… Incorporation of strontium in a surface-active biomaterial offers the … strontium on bone
remodelling will not be discussed here, which is still not fully understood, but in summary strontium …

… were recorded as described by Chahl and O'Donnell (1967). The … described by Chahl and
O'Donnell (1967) and O'Donnell (1968). … Chahl, LA and SR O'Donnell, 1967, The interaction of …

… Future trials to evaluate the impact of strontium ranelate treatment on BMD, including the
effect on the elimination of bone strontium in patients switching to other anti‐resorptive …

It has been demonstrated that the chronotropic responses to sympathomimetic amines in rat
atria were mediated only by beta-1 adrenoceptors. This was like guinea pig (beta-1) but …