The metabolism of the anticonvulsant drug mephenytoin exhibits a genetic polymorphism in
humans, with the poor metabolizer trait being inherited in an autosomal recessive fashion. …

A genetic polymorphism in the metabolism of the anticonvulsant drug (S)-mephenytoin has
been well documented in humans. There are marked interracial differences in the frequency …

Thirty-one structurally diverse marketed central nervous system (CNS)-active drugs, one active
metabolite, and seven non-CNS-active compounds were tested in three P-glycoprotein (P…

Major reasons preventing many early candidates reaching market are the inappropriate ADME
(absorption, distribution, metabolism and excretion) properties and drug-induced toxicity. …

Candida albicans is the most common human fungal pathogen, causing infections that range
from mucous membranes to systemic infections. The present article provides an overview …

While P-glycoprotein (PGP, ABCB1) is known to play an important role in drug exclusion at
the blood brain barrier (BBB), less is known about the contribution of other members in the …

The larvicidal activity of essential oils of four species of Piper from the Amazon Forest was
tested using third-instar larvae of Aedes aegypti. The oils were extracted by steam distillation …

This study aimed to establish a nutritional ranking of 30 genotypes of cowpea (Vigna
unguiculata L. Walp). The results showed the proximate composition varies among genotypes in …

Anacardic acid, cardanol and cardol, the main constituents of natural cashew nut shell liquid
(CNSL), were obtained by solvent extraction and assayed for antioxidant, larvicidal and …

In Northeastern Brazil visceral leishmaniasis is endemic with lethal cases among humans and
dogs. Treatment is toxic and 5–10% of humans die despite treatment. The aim of this work …