Chronic inflammation is a key feature of many airway diseases. Leukocyte accumulation in
the lung has the capacity to mediate many aspects of the pathophysiology of such diseases …

Background: Patients with chronic obstructive pulmonary disease (COPD) have increased
numbers of neutrophils and macrophages in their lungs. Growth related oncogene-α (GROα) …

… Dr Traves acknowledges ALTANA Canada for postdoctoral fellowship support. Dr Proud
is the recipient of a Canada Research Chair in Inflammatory Airway Diseases and thanks the …

Leukocyte migration is critical to maintaining host defense, but uncontrolled cellular infiltration
into tissues can lead to chronic inflammation. In the lung, such diseases include chronic …

Asthma and chronic obstructive pulmonary disease (COPD) are different conditions with
contrasting airway inflammation and parenchymal disease patterns. A number of matrix …

Background COPD is associated with increased numbers of CD4 + and CD8 + lymphocytes
and macrophages in the small airways and lung parenchyma. The chemokines regulating T-…

Peroxisome proliferator‐activated receptors (PPARs) are nuclear receptors that heterodimerize
with the retinoid X receptor and then modulate at the transcriptional level the function of …

Human rhinovirus (HRV) infections induce epithelial cell production of chemokines that may
contribute to the pathogenesis of exacerbations of chronic obstructive pulmonary disease (…

Human rhinovirus (HRV) infections trigger acute exacerbations of chronic obstructive
pulmonary disease (COPD) and asthma. The human airway epithelial cell is the primary site of …

Chronic obstructive pulmonary disease (COPD) patients exhibit chronic inflammation, both in
the lung parenchyma and the airways, which is characterised by an increased infiltration of …