Paclitaxel, one of the most commonly used cancer chemotherapeutic drugs, effectively
extends the progression-free survival of breast, lung, and ovarian cancer patients. However, …

Although paclitaxel effectively treats various cancers, its debilitating peripheral neuropathic
pain side effects often persist long after treatment has ended. Therefore, a compelling need …

Chemotherapy-induced peripheral neuropathy (CIPN), a consequence of peripheral nerve
fiber dysfunction or degeneration, continues to be a dose-limiting and debilitating side effect …

Various antitumor drugs, including paclitaxel, frequently cause chemotherapy-induced
peripheral neuropathy (CIPN) that can be sustained even after therapy has been completed. The …

Studies in animal models have suggested that nicotine, an agonist of nicotinic acetylcholine
receptors, may have the potential to prevent and/or reverse the peripheral neuropathy …

Autophagy and senescence are both well-established responses to chemotherapy and
radiation that often occur in parallel, contributing to growth arrest in tumor cells. However, it has …

Autophagy is a cellular degradation mechanism involving protein turnover as well as the
recycling of excessive and dysfunctional organelles. Autophagy is generally considered to …

While chemotherapy has played a significant role in the survival of cancer patients, exposure
to drugs such as the taxanes, platinum-based compounds, and bortezomib often results in …

While cellular senescence has long been recognized as an irreversible form of growth arrest,
evidence in the literature has suggested that subpopulations of senescent tumor cells may …

… By Sarah Lauren Kyte, BS A dissertation submitted in partial fulfillment of the requirements
for the degree of … Lauren Kyte performed the nesting and novelty suppressed feeding assays. …