[HTML][HTML] The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids
…, DM Ignar, SM Foord, A Wise, SJ Dowell - Journal of Biological …, 2003 - ASBMB
GPR41 and GPR43 are related members of a homologous family of orphan G protein-coupled
receptors that are tandemly encoded at a single chromosomal locus in both humans and …
receptors that are tandemly encoded at a single chromosomal locus in both humans and …
Two steps in the assembly of complexes at yeast replication origins in vivo
JFX Diffley, JH Cocker, SJ Dowell, A Rowley - Cell, 1994 - cell.com
The integration of chromosomal DNA replication into the eukaryotic cell cycle might involve
temporal regulation of interactions between cellular factors and replication origins. We show …
temporal regulation of interactions between cellular factors and replication origins. We show …
[HTML][HTML] Molecular identification of high and low affinity receptors for nicotinic acid
…, K Steplewski, A Green, AJ Brown, SJ Dowell… - Journal of Biological …, 2003 - ASBMB
Nicotinic acid has been used clinically for over 40 years in the treatment of dyslipidemia
producing a desirable normalization of a range of cardiovascular risk factors, including a marked …
producing a desirable normalization of a range of cardiovascular risk factors, including a marked …
Yeast assays for G-protein-coupled receptors
SJ Dowell, AJ Brown - receptors and channels, 2002 - Taylor & Francis
… SJ Dowell … Address correspondence to SJ Dowell, Gene Expression and Protein
Biochemistry, GlaxoSmithkline, Medicines Research Centre, Gunnels Wood Road, Stevenage, …
Biochemistry, GlaxoSmithkline, Medicines Research Centre, Gunnels Wood Road, Stevenage, …
Functional coupling of mammalian receptors to the yeast mating pathway using novel yeast/mammalian G protein α‐subunit chimeras
…, C Paddon, C Plumpton, MA Romanos, SJ Dowell - Yeast, 2000 - Wiley Online Library
The expression of mammalian G protein coupled receptors (GPCRs) in S. cerevisiae provides
a powerful assay system for functional analysis, ligand identification and pharmaceutical …
a powerful assay system for functional analysis, ligand identification and pharmaceutical …
Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo
SJ Dowell, P Romanowski, JFX Diffley - Science, 1994 - science.org
DNA replication in the budding yeast Saccharomyces cerevisiae initiates from origins of
specific DNA sequences during S phase. A screen based on two- and one-hybrid approaches …
specific DNA sequences during S phase. A screen based on two- and one-hybrid approaches …
[HTML][HTML] Receptor activity-modifying protein-directed G protein signaling specificity for the calcitonin gene-related peptide family of receptors
…, M Harris, R Hodgson, A Shah, SJ Dowell… - Journal of Biological …, 2016 - ASBMB
The calcitonin gene-related peptide (CGRP) family of G protein-coupled receptors (GPCRs)
is formed through the association of the calcitonin receptor-like receptor (CLR) and one of …
is formed through the association of the calcitonin receptor-like receptor (CLR) and one of …
[HTML][HTML] Unlocking the secrets of the gatekeeper: methods for stabilizing and crystallizing GPCRs
…, MM Hann, KJ Smith, JA Hubbard, SJ Dowell… - … et Biophysica Acta (BBA …, 2013 - Elsevier
G-protein coupled receptors (GPCRs) are integral membrane cell surface receptors with key
roles in mediating the cellular responses to a wide range of biologically relevant molecules …
roles in mediating the cellular responses to a wide range of biologically relevant molecules …
[HTML][HTML] Modulation of glucagon receptor pharmacology by receptor activity-modifying protein-2 (RAMP2)
…, M Pardamwar, CA Reynolds, SJ Dowell… - Journal of Biological …, 2015 - ASBMB
The glucagon and glucagon-like peptide-1 (GLP-1) receptors play important, opposing roles
in regulating blood glucose levels. Consequently, these receptors have been identified as …
in regulating blood glucose levels. Consequently, these receptors have been identified as …
Pharmacology of GPR55 in yeast and identification of GSK494581A as a mixed-activity glycine transporter subtype 1 inhibitor and GPR55 agonist
…, PL Nichols, PC Staton, A Wise, SJ Dowell - … of Pharmacology and …, 2011 - ASPET
GPR55 is a G protein-coupled receptor activated by l-α-lysophosphatidylinositol and
suggested to have roles in pain signaling, bone morphogenesis, and possibly in vascular …
suggested to have roles in pain signaling, bone morphogenesis, and possibly in vascular …