Regulation of phosphoinositide-specific phospholipase C

SG Rhee - Annual review of biochemistry, 2001 - annualreviews.org
▪ Abstract Eleven distinct isoforms of phosphoinositide-specific phospholipase C (PLC), which
are grouped into four subfamilies (β, γ, δ, and ∍), have been identified in mammals. These …

Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling

SG Rhee, HZ Chae, K Kim - Free radical biology and Medicine, 2005 - Elsevier
The observation that purified yeast glutamine synthetase is rapidly inactivated in a thiol-containing
buffer yet retains activity in crude extracts containing the same thiol led to our …

[HTML][HTML] Regulation of phosphoinositide-specific phospholipase C isozymes

SG Rhee, YS Bae - Journal of biological chemistry, 1997 - ASBMB
The hydrolysis of a minor membrane phospholipid, phosphatidylinositol 4, 5-bisphosphate (PIP2),
1 by a specific phospholipase C (PLC) is one of the earliest key events in the …

H2O2, a Necessary Evil for Cell Signaling

SG Rhee - Science, 2006 - science.org
H2O2 production, protection, and signaling actions. Activation of various cell surface receptors
activates Nox situated either in the plasma membrane or in the membrane of organelles …

[HTML][HTML] Epidermal growth factor (EGF)-induced generation of hydrogen peroxide: role in EGF receptor-mediated tyrosine phosphorylation

…, IC Baines, E Tekle, PB Chock, SG Rhee - Journal of Biological …, 1997 - ASBMB
Recent evidence indicates that reactive oxygen species (ROS) may function as intracellular
messengers in receptor signaling pathways. The possible role of ROS in epidermal growth …

[HTML][HTML] Reversible inactivation of the tumor suppressor PTEN by H2O2

…, KS Yang, J Kwon, C Lee, W Jeong, SG Rhee - Journal of Biological …, 2002 - ASBMB
The tumor suppressor PTEN regulates cell migration, growth, and survival by removing the 3′-phosphate
of phosphoinositides. Exposure of purified PTEN or of cells to H 2 O 2 …

Thioredoxin-dependent peroxide reductase from yeast.

HZ Chae, SJ Chung, SG Rhee - Journal of biological chemistry, 1994 - ASBMB
A 25-kDa antioxidant enzyme that provides protection against oxidation systems capable of
generating reactive oxygen and sulfur species has previously been identified. The nature of …

[HTML][HTML] Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor

SR Lee, KS Kwon, SR Kim, SG Rhee - Journal of Biological Chemistry, 1998 - ASBMB
Stimulation of various cells with growth factors results in a transient increase in the
intracellular concentration of H 2 O 2 that is required for growth factor-induced protein tyrosine …

The impact of the degrees of operating and financial leverage on systematic risk of common stock

GN Mandelker, SG Rhee - Journal of financial and quantitative …, 1984 - cambridge.org
The capital asset pricing model postulates that the equilibrium return on any risky security is
equal to the sum of the risk-free rate of return and a risk premium measured by the product …

Hydrogen peroxide: a key messenger that modulates protein phosphorylation through cysteine oxidation

SG Rhee, YS Bae, SR Lee, J Kwon - Science's STKE, 2000 - science.org
Rhee et al. discuss recent findings on the role of H 2 O 2 in signal transduction. Specifically,
H 2 O 2 appears to oxidize active site cysteines in phosphatases, thereby inactivating them. …