Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor
JW Polli, JL Jarrett, SD Studenberg… - Pharmaceutical …, 1999 - Springer
Purpose. To determine the role of P-glycoprotein (Pgp) on the CNS penetration of the HIV
protease inhibitor (PI) amprenavir (141W94) and to test the hypothesis that co-administration …
protease inhibitor (PI) amprenavir (141W94) and to test the hypothesis that co-administration …
Preclinical pharmacology and pharmacokinetics of GW433908, a water-soluble prodrug of the human immunodeficiency virus protease inhibitor amprenavir
…, JA Salisbury, AD Searle, SD Studenberg… - Antimicrobial agents …, 2004 - Am Soc Microbiol
GW433908 is the water-soluble, phosphate ester prodrug of the human immunodeficiency
virus type 1 protease inhibitor amprenavir (APV). A high-yield synthesis of GW433908 is …
virus type 1 protease inhibitor amprenavir (APV). A high-yield synthesis of GW433908 is …
Digoxin-like immunoreactivity eliminated from serum by centrifugal ultrafiltration before fluorescence polarization immunoassay of digoxin.
RH Christenson, SD Studenberg… - Clinical …, 1987 - academic.oup.com
Digoxin determined in the Abbott "TDx" by fluorescence polarization immunoassay by the
manufacturer's recommended method involving precipitation of protein with 5-sulfosalicylic …
manufacturer's recommended method involving precipitation of protein with 5-sulfosalicylic …
Metabolic Disposition and Pharmacokinetics of [14C]‐Amprenavir, a Human Immunodeficiency Virus Type 1 (HIV‐1) Protease Inhibitor, Administered As a Single Oral …
…, D Slain, TM Kerkering, SD Studenberg… - The Journal of …, 2001 - Wiley Online Library
The objective of this study was to determine the metabolic profile, routes of elimination, and
total recovery of amprenavir and its metabolites after a single oral dose of [ 14 C]‐amprenavir…
total recovery of amprenavir and its metabolites after a single oral dose of [ 14 C]‐amprenavir…
A robotics-based liquid chromatographic assay for the measurement of atovaquone in plasma
SD Studenberg, JD Long, JH Woolf, CJ Bruner… - … of pharmaceutical and …, 1995 - Elsevier
A precise and specific robotics-based liquid chromatographic (LC) method for measuring
atovaquone concentrations in plasma was developed and validated, and the method was …
atovaquone concentrations in plasma was developed and validated, and the method was …
Impaired biliary excretion of acetaminophen glucuronide in the isolated perfused rat liver after acute phenobarbital treatment and in vivo phenobarbital pretreatment.
SD Studenberg, KL Brouwer - Journal of Pharmacology and Experimental …, 1992 - ASPET
The influence of phenobarbital (PB) on the hepatobiliary disposition of acetaminophen (APAP),
acetaminophen glucuronide (AG) and acetaminophen sulfate (AS) was examined in the …
acetaminophen glucuronide (AG) and acetaminophen sulfate (AS) was examined in the …
Hepatic disposition of acetaminophen and metabolites: Pharmacokinetic modeling, protein binding and subcellular distribution
SD Studenberg, KLR Brouwer - Biochemical pharmacology, 1993 - Elsevier
… Acetaminophen, AG and acetaminophen sulfate (AS) were not bound extensively in
hepatic cytosol (mean ± SD unbound fractions were 0.90 ± 0.08, 0.97 ± 0.08, and 0.88 ± 0.06, …
hepatic cytosol (mean ± SD unbound fractions were 0.90 ± 0.08, 0.97 ± 0.08, and 0.88 ± 0.06, …
Effect of phenobarbital andp-hydroxyphenobarbital glucuronide on acetaminophen metabolites in isolated rat hepatocytes: Use of a kinetic model to examine the …
SD Studenberg, KLR Brouwer - Journal of pharmacokinetics and …, 1993 - Springer
… SD Studenberg and KLR Brouwer. Impaired biliary excretion of acetaminophen
glucuronide in the isolated perfused rat liver after acute phenobarbital treatment and in vivo …
glucuronide in the isolated perfused rat liver after acute phenobarbital treatment and in vivo …
Phenacetin and acetaminophen metabolism in the isolated perfused rat liver. Precursor concentration influences the selection of kinetic parameters to assess hypoxic …
SD Studenberg, KL Brouwer - Drug metabolism and disposition, 1991 - ASPET
Subnormal oxygen concentrations affect a host of cellular functions and can exist under
normal or pathological conditions. The present study examined the effects of hypoxia on …
normal or pathological conditions. The present study examined the effects of hypoxia on …
Characterization of p? hydroxyphenobarbital glucuronide generated from immobilized rat hepatic UDP? glucuronosyltransferase
SD Studenberg, DL Price-Raybuck… - Journal of …, 1995 - hero.epa.gov
IPA COPYRIGHT: ASHP A modified method for the in vitro generation of glucuronides was
developed using immobilized rat hepatic uridine-5'-diphosphoglucuronosyltransferase …
developed using immobilized rat hepatic uridine-5'-diphosphoglucuronosyltransferase …