The orphan nuclear receptor RORβ is expressed in areas of the central nervous system which
are involved in the processing of sensory information, including spinal cord, thalamus and …

… Habituated rats were then dosed with d-amphetamine (0.8 mg/kg, sc, flank, dose producing
a significant potentiation of LMA, as determined in a previous dose–response evaluation to d-…

In kindling models of epilepsy, the period during which repeated stimulation evokes intensifying
seizures is attributed to an underlying epileptogenic process, and the point at which …

The impact of effluent discharges continues to be an important issue for the pulp manufacturing
industry. Considerable progress has been made in pollution prevention to minimize …

… –0.5 µg/kg SC) and diazepam (1–1.75 mg/kg SC), also … (0.2–50 µg/kg SC) significantly
increased the amount of time … –50 µg/kg SC) and chlordiazepoxide (0.3–3.0 mg/kg SC). These …

The pathogenic form of the cyclooxygenase (COX) enzyme, COX-2, is also constitutively
present in the spinal cord and has been implicated in chronic pain states in rat and man. A …

Starting from a series of 7-linked tetrahydroisoquinoline derivatives, as exemplified by SB-270664,
a new series of 8,8-dimethylnaphthyridine compounds has been identified. SAR …

… These effects were similar to that evoked by a dose (1.75 mg/kg sc) of diazepam which
we previously determined to be maximally effective (fig. 1). Diazepam was included in each …

Prevention of epileptogenesis in patients with acute brain damaging insults like status epilepticus
(SE) is a major challenge. We investigated whether lamotrigine (LTG) treatment started …

JZP-4 is a potent calcium and sodium channel blocker, which is currently being evaluated in
patients as an anticonvulsant and mood stabilizer. In the current studies, JZP-4 was …