NR1/NR2A is a subtype of N-methyl-d-aspartate receptors (NMDARs), which are glutamate
and glycine-gated Ca 2+ -permeable channels highly expressed in the central nervous …

Objective: Herein we demonstrate the successful development of a new RORγt-enhanced IL-17F
promoter-luciferase reporter assay and its use in a parallel high throughput screening …

The epithelial sodium channel (ENaC) plays a crucial role in salt and water homeostasis
and is primarily involved in sodium reabsorption in the kidney and lung. Modulators of ENaC …

Ionotropic glutamate receptors (iGluRs) transduce signals derived from release of the
excitatory neurotransmitter glutamate from pre-synaptic neurons into excitation of post-synaptic …

It is known that NMDA receptor stimulation can activate or inhibit the extracellular signal-regulated
kinase (ERK) signalling cascade, a key pathway involved in neuronal plasticity and …

Highlights • The NMDA receptor is a membrane protein critical to mammalian learning and
memory. • Heterotetrameric NMDARs consist of three structured domains that regulate ion flux…

The GluN2D subunit of the NMDA receptor is prominently expressed in the basal ganglia
and associated brainstem nuclei, including the subthalamic nucleus (STN), globus pallidus, …

NMDA-type glutamate receptors (NMDARs) are ligand-gated ion channels that mediate
excitatory neurotransmission in the CNS. Here we describe functional and single-channel …

The N-methyl-d-aspartate receptor plays a critical role in central nervous system processes.
Its diverse properties, as well as hypothesized role in neurological disease, render NMDA …

COPD is a leading cause of morbidity and mortality worldwide. Long-term cigarette smoking
is the cause of > 90% of COPD cases in Westernized countries. However, only a fraction of …