Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by activation
of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that drive …

Background and Aims Since its market release, gabapentin has been presumed to have no
abuse potential and subsequently has been prescribed widely off‐label, despite increasing …

Rationale Cannabidiol (CBD) products lacking regulatory approval are being used to self-treat
a myriad of conditions and for their unsubstantiated health benefits. The scientific …

Objective The purpose of this study was to characterize the acute effects of buprenorphine,
an opioid partial (μ‐agonist, across a wide range of doses in comparison to methadone. …

Background Opioid dependence is a chronic, relapsing disorder with important public
health implications. Methods In a 17-week randomized study of 220 patients, we compared …

Background Individuals with opioid use disorder may be at heightened risk of opioid
overdose during the COVID-19 period of social isolation, economic distress, and disrupted …

Buprenorphine, a mixed opioid agonist-antagonist, is being investigated as a treatment for
opioid dependence. This study compared the acute subjective and physiological effects of …

… Triangles indicate sublingual (SL) buprenorphine … ) SL buprenorphine-naloxone doses
were converted to SC buprenorphine dose equivalents based on the following conversions: SL …

Rationale: The availability of the highly selective and specific kappa opioid agonist enadoline
provides an opportunity to explore the function of kappa receptors in humans and their …

… Drs Lofwall and Walsh are on the steering committee for the … In addition, Dr Walsh has
received payment for chairing and … Dr Walsh has received payment for service on a Safety …