CGP 39653 (D,L-(E)-2-amino-4-propyl-5-phosphono-3-pentenoic acid) was initially
discovered to inhibit the binding of [ 3 H]L-glutamate and [ 3 H]3-((±)2-carboxypiperazin-4-yl)-propyl-…

Objective: Use diffusion tensor imaging to investigate white matter alterations associated with
blast exposure with or without acute symptoms of traumatic brain injury (TBI). Participants: …

CGS 19755 (cis-4-phosphonomethyl-2-piperidine carboxylic acid), a rigid analogue of 2-amino-5-phosphonopentanoic
acid (AP5), is one of the most potent competitive N-methyl-D-…

A new 5‐HT 1A receptor antagonist ligand, [ 3 H]p‐MPPF, 4‐(2′‐methoxy‐)‐phenyl‐1‐[2′‐(N‐2′‐pyridyl)‐p‐fluorobenzamido]ethyl‐piperazine,
was prepared and characterized. It …

Earlier studies have demonstrated that the vasoactive compound CV 1808 displays 10-fold
selectivity for the adenosine A2 receptor, and as such, was the first reported A2-selective …

The radiochemical synthesis and pharmacological properties are described of [ 3 H]RY 80 (ethyl-8-acetylene-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5a][1,4]benzodiazepine-3-…

A strychnine-insensitive glycine binding site is located on the N-methyl-d-aspartate (NMDA)-preferring
glutamate receptor complex. Kynurenic acid analogs are antagonists at this …

G protein-coupled receptors (GPCRs) represent the single largest molecular target of therapeutic
drugs currently on the market, and are also the most common target in high throughput …

This work examines the autoradiographic distribution of serotonin (5-HT) receptor subtypes
in rat, guinea pig and human brain, using [ 3 H]5-HT and [ 3 H]5-CT as ligands. Different …

The NMDA subtype of glutamate receptors is allosterically linked to a strychnine-insensitive
glycine regulatory site. Kynurenic acid and its halogenated derivatives are non-competitive …