User profiles for S A Abdel-Aziz
Salah A. Abdel-AzizProfessor of Pharmaceutical Chemistry Verified email at deraya.edu.eg Cited by 566 |
Molecular hybrids: A five-year survey on structures of multiple targeted hybrids of protein kinase inhibitors for cancer therapy
Protein kinases have grown over the past few years as a crucial target for different cancer
types. With the multifactorial nature of cancer, and the fast development of drug resistance for …
types. With the multifactorial nature of cancer, and the fast development of drug resistance for …
Design, synthesis, and biological evaluation of new pyrimidine-5-carbonitrile derivatives bearing 1, 3-thiazole moiety as novel anti-inflammatory EGFR inhibitors with …
A new series of pyrimidine-5-carbonitrile derivatives 8a-p carrying the 1,3-thiazole moiety
has been designed and synthesized as novel anti-inflammatory EGFR inhibitors with cardiac …
has been designed and synthesized as novel anti-inflammatory EGFR inhibitors with cardiac …
Design, synthesis and anticancer activity of new monastrol analogues bearing 1, 3, 4-oxadiazole moiety
FAF Ragab, SM Abou-Seri, SA Abdel-Aziz… - European Journal of …, 2017 - Elsevier
A series of dihydropyrimidine (DHPM) derivatives bearing 1,3,4-oxadiazole moiety was
designed and synthesized as monastrol analogues. The new compounds were screened for …
designed and synthesized as monastrol analogues. The new compounds were screened for …
Epidemiology and public health significance of Cryptosporidium isolated from cattle, buffaloes, and humans in Egypt
…, AE Abdel-Ghany, GK Abdel-Latef, SA Abdel-Aziz… - Parasitology …, 2016 - Springer
The epidemiology and public health significance of Cryptosporidium species and genotypes
were investigated in Beni-Suef Governorate, Egypt. A total of 610 animal fecal samples (…
were investigated in Beni-Suef Governorate, Egypt. A total of 610 animal fecal samples (…
Design and synthesis of pyrimidine-5-carbonitrile hybrids as COX-2 inhibitors: anti-inflammatory activity, ulcerogenic liability, histopathological and docking studies
Two new series of 1,3,4-oxadiazole and coumarin derivatives based on pyrimidine-5-carbonitrile
scaffold have been synthesized and evaluated for their COX-1/COX-2 inhibitory activity. …
scaffold have been synthesized and evaluated for their COX-1/COX-2 inhibitory activity. …
Design, synthesis, and antibacterial evaluation of new quinoline-1, 3, 4-oxadiazole and quinoline-1, 2, 4-triazole hybrids as potential inhibitors of DNA gyrase and …
DNA gyrase and topoisomerase IV (topo IV) inhibitors are among the most interesting
antibacterial drug classes without antibacterial pipeline representative. Twenty-four new quinoline-…
antibacterial drug classes without antibacterial pipeline representative. Twenty-four new quinoline-…
Design and synthesis of new 1, 6-dihydropyrimidin-2-thio derivatives targeting VEGFR-2: Molecular docking and antiproliferative evaluation
A series of new 1,6-dihydropyrimidin-2-thiol derivatives (scaffold A) as VEGFR-2 inhibitors
has been designed and synthesized. Compounds 3a, 3b, 3e and 4b have been selected for in …
has been designed and synthesized. Compounds 3a, 3b, 3e and 4b have been selected for in …
Towards anticancer fluoroquinolones: A review article
MAA Abdel‐Aal, SA Abdel‐Aziz… - Archiv der …, 2019 - Wiley Online Library
Different studies about the anticancer potential of several medically used antibacterial
fluoroquinolones have been established. Fluoroquinolone derivatives, like some anti‐cancer …
fluoroquinolones have been established. Fluoroquinolone derivatives, like some anti‐cancer …
JNK signaling as a target for anticancer therapy
The JNKs are members of mitogen-activated protein kinases (MAPK) which regulate many
physiological processes including inflammatory responses, macrophages, cell proliferation, …
physiological processes including inflammatory responses, macrophages, cell proliferation, …
[HTML][HTML] Novel 1, 2, 4-oxadiazole/pyrrolidine hybrids as DNA gyrase and topoisomerase IV inhibitors with potential antibacterial activity
FOA Frejat, Y Cao, H Zhai, SA Abdel-Aziz… - Arabian Journal of …, 2022 - Elsevier
DNA gyrase is a promising target for antibacterial agents. Several classes of small-molecule
inhibitors have been discovered in recent decades, but none of these have reached the …
inhibitors have been discovered in recent decades, but none of these have reached the …