The focal adhesion kinase (FAK) gene encodes a tyrosine kinase (p125 FAK ) thought to be
involved in signal transduction pathways used in cell adhesion, motility, and anchorage-…

Expression of the PTEN tumor suppressor is frequently lost in breast cancer in the absence
of mutation or promoter methylation through as yet undetermined mechanisms. In this study, …

Hormone signaling is important in a number of disease states, and hormone receptors are
effective therapeutic targets. PGRMC1 (progesterone receptor membrane component 1) is a …

The focal adhesion kinase (FAK) is a nonreceptor protein tyrosine kinase implicated in
integrin-mediated signal transduction pathways, oncogenic transformation by v-src, and the …

Focal adhesion kinase (FAK) is a protein tyrosine kinase expressed in invasive breast
cancer that regulates antiapoptotic signaling. We have examined FAK expression by …

Background: The FAK gene encodes a 125-kDa tyrosine kinase (p125 FAK ) involved in
signal transduction pathways used in cell adhesion, motility, and anchorage-independent …

Tumor cells resist the apoptotic stimuli associated with invasion and metastasis by activating
survival signals that suppress apoptosis. Focal adhesion kinase (FAK), a tyrosine kinase …

The focal adhesion kinase (FAK) is a mediator of cell-extracellular matrix signaling events
and is overexpressed in tumor cells. In order to rapidly down-regulate FAK function in normal …

Using a PCR‐based cloning technique, we have isolated a series of DNA fragments coding
for tyrosine kinases that are expressed in a metastatic human colon tumor, and have …

Tumorigenesis requires the concerted action of multiple pathways, including pathways that
stimulate proliferation and increase metabolism. Progesterone receptor membrane …