Dual inhibition of interleukin-23 and interleukin-17 offers superior efficacy in mouse models of autoimmunity
…, DJ Shuster, Y Song, V Borowski, RL Thomas… - … of Pharmacology and …, 2015 - ASPET
Therapies targeting either interleukin (IL)-23 or IL-17 have shown promise in treating T
helper 17 (Th17)–driven autoimmune diseases. Although IL-23 is a critical driver of IL-17, …
helper 17 (Th17)–driven autoimmune diseases. Although IL-23 is a critical driver of IL-17, …
Oocyte age and preconceptual alcohol use are highly correlated with epigenetic imprinting of a noncoding RNA (nc886)
…, SL Thomas, Z Madaj, L Brink… - Proceedings of the …, 2021 - National Acad Sciences
Genomic imprinting occurs before fertilization, impacts every cell of the developing child, and
may be sensitive to environmental perturbations. The noncoding RNA, nc886 (also called …
may be sensitive to environmental perturbations. The noncoding RNA, nc886 (also called …
[HTML][HTML] A real-world comparison of tisagenlecleucel and axicabtagene ciloleucel CAR T cells in relapsed or refractory diffuse large B cell lymphoma
…, J Abraham, A Chauchet, L Drieu La Rochelle… - Nature medicine, 2022 - nature.com
Axicabtagene ciloleucel (axi-cel) and tisagenlecleucel (tisa-cel) have both demonstrated
impressive clinical activity in relapsed/refractory (R/R) diffuse large B cell lymphoma (DLBCL). …
impressive clinical activity in relapsed/refractory (R/R) diffuse large B cell lymphoma (DLBCL). …
From the culture of poverty to the culture of single motherhood: The new poverty paradigm
SL Thomas - Women & Politics, 1994 - Taylor & Francis
Women in the United States have long suffered high rates of poverty,yet it was only in the
late 1970s that the "feminization of poverty" was recognized. Instead of using the emerging …
late 1970s that the "feminization of poverty" was recognized. Instead of using the emerging …
Noncanonical scaffolding of Gαi and β-arrestin by G protein–coupled receptors
INTRODUCTION G protein–coupled receptors (GPCRs) are a superfamily of seven
transmembrane-spanning receptors and are the target of 30% of all US Food and Drug …
transmembrane-spanning receptors and are the target of 30% of all US Food and Drug …
[HTML][HTML] Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network
LGR5 is a Wnt pathway associated G protein-coupled receptor (GPCR) that serves as a
molecular determinant of stem cells in numerous tissues including the intestine, stomach, hair …
molecular determinant of stem cells in numerous tissues including the intestine, stomach, hair …
The role of reactive oxygen and nitrogen species in the response of airway epithelium to particulates.
…, BM Fischer, NF Jiang, LG Rochelle… - Environmental …, 1997 - ehp.niehs.nih.gov
Epidemiologic and occupational studies indicate adverse health effects due to inhalation of
particulate air pollutants, but precise biologic mechanisms responsible have yet to be fully …
particulate air pollutants, but precise biologic mechanisms responsible have yet to be fully …
[HTML][HTML] Mitochondrial transplant after ischemia reperfusion promotes cellular salvage and improves lung function during ex-vivo lung perfusion
CM Cloer, CS Givens, LK Buie, LK Rochelle… - The Journal of Heart and …, 2023 - Elsevier
Background In lung transplantation, ischemia-reperfusion injury associated with mitochondrial
damage can lead to graft rejection. Intact, exogenous mitochondria provide a unique …
damage can lead to graft rejection. Intact, exogenous mitochondria provide a unique …
[HTML][HTML] Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness
The leucine-rich G protein-coupled receptor-5 (LGR5) is expressed in adult tissue stem cells
of many epithelia, and its overexpression is negatively correlated with cancer prognosis. …
of many epithelia, and its overexpression is negatively correlated with cancer prognosis. …
[HTML][HTML] Mesenchymal stromal cell-derived extracellular vesicles reduce lung inflammation and damage in nonclinical acute lung injury: Implications for COVID-19
Mesenchymal stem cell derived extracellular vesicles (MSC-EVs) are bioactive particles that
evoke beneficial responses in recipient cells. We identified a role for MSC-EV in immune …
evoke beneficial responses in recipient cells. We identified a role for MSC-EV in immune …