The amyloid hypothesis, which states that β-amyloid (Aβ) aggregates cause the onset and
progression of Alzheimer’s disease (AD), is a leading proposal to explain AD aetiology. …

Corticotropin releasing factor (or hormone, CRF or CRH) is a major modulator of the body’s
responses to stress, and modulation of CRF receptor function has become an important …

Presenilins are integral membrane protein involved in the production of amyloid β-protein.
Mutations of the presenilin-1 and -2 gene are associated with familial Alzheimer's disease …

During the course of our research efforts to develop a potent and selective γ-secretase
inhibitor for the treatment of Alzheimer's disease, we investigated a series of carboxamide-…

An isocratic HPLC method to measure endogenous N‐acetyl‐aspartyl‐glutamate (NAAG)
and N‐acetyl‐aspartate (NAA) is described. After removal of primary amines by passage of …

Kainic acid (KA), a conformationally restricted analogue of glutamic acid, exhibits potent
neuroexcitatory 1 and neurotoxic properties 2 . The mechanism of the neurotoxicity of KA, …

Schizophrenia is associated with alterations in working memory that reflect dysfunction of
dorsolateral prefrontal cortex (DLPFC) circuitry. Working memory depends on the activity of …

CRF 1 antagonists DMP696 and DMP904 were designed as drug development candidates
for the treatment of anxiety and depression. Both compounds display nanomolar affinity for …

Non‐Technical Summary In multiple brain regions, endogenous cannabinoids suppress
inhibitory synaptic transmission; however, the biochemical/molecular pathways for …

This report describes the syntheses and structure−activity relationships of 8-(substituted
pyridyl)pyrazolo[1,5-a]-1,3,5-triazine corticotropin releasing factor receptor-1 (CRF 1 ) receptor …